Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Adverse drug reactions

Duration of finasteride and dutasteride treatment linked to long-term erectile dysfunction

Study results show 1.4% of men exposed to 5α-reductase inhibitors finasteride and dutasteride developed erectile dysfunction that continued for at least 90 days after stopping treatment.

Case reports have linked persistent erectile dysfunction with use of the 5α-reductase inhibitors finasteride and dutasteride. However, it has been claimed that the risk of sexual adverse effects does not increase with longer exposure to the drugs and the effects resolve in men who stop taking them.

To assess this, a team of researchers studied data on 11,909 men who took a 5α-reductase inhibitor and had no history of erectile dysfunction.

Overall, 167 (1.4%) men developed persistent erectile dysfunction that continued for at least 90 days after stopping treatment (median: 1,348 days). In multivariable analysis, the duration of exposure to a 5α-reductase inhibitor was a more accurate predictor of persistent erectile dysfunction than many known risk factors, including age, hypertension and depression.

Writing in PeerJ[1] (online, 9 March 2017), the researchers say their findings will be of particular interest to prescribers or patients considering treatment with a 5α-reductase inhibitor.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20202479

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Molecular structure of finasteride

Jobs you might like

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.