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Antimicrobial stewardship

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  • Micrograph of Acinetobacter baumannii bacteria

    Ceftazidime-avibactam: a novel cephalosporin/β-lactamase inhibitor Subscription

    Over the past decade, infections caused by multidrug-resistant Gram-negative organisms have increased. The limited availability in treatment options for these infections prompted both the UK to create a five-year antimicrobial resistance strategic plan to stimulate the development of new antibiotics, and the Infectious Diseases Society of America to call for ten new antimicrobial agents to be developed by 2020. Ceftazidime-avibactam is a combination of a third-generation ...

  • Scanning electron micrograph (SEM) of tuberculosis (TB) bacteria infecting macrophages

    Fluoroquinolones for treating tuberculosis Subscription

    Tuberculosis (TB) remains a significant global health and socioeconomic challenge. The duration of current anti-TB therapies, the adverse effects of certain anti-TB drugs and the growing problem of drug-resistant TB on an international scale mean that it is imperative for new, effective and safe treatment regimens to be developed. Fluoroquinolones are a class of drugs that have been used in the treatment of TB for several decades. This article provides an overview of the current treatment ...

  • Micrograph of Clostridium difficile bacteria

    Clostridium difficile: diagnosis and treatment update

    There are around 12,000 cases of Clostridium difficile infection (CDI) each year in the UK and during 1999 to 2007, deaths from CDI peaked at around 4,000 per year. This article summarises diagnosis and management, as well as the current therapeutic options for CDI, including faecal microbiota transplant.

  • Collage showing MRSA, research and antibiotics

    New approaches to overcoming antimicrobial resistance Subscription

    As antibiotic resistance continues to threaten the treatment of various infections, researchers are looking for new ways to supplement and in some cases replace failing antimicrobial drugs.

  • Illustration antibiotic destroying bacteria

    Principles of initiating antimicrobial therapy and empiric prescribing Subscription

    Healthcare professionals should be aware of the principles of antimicrobial treatment and the need to reduce inappropriate prescribing to retain the effectiveness of drugs currently available.

  • Helicobacter pylori infections and treatment remain an unsolved problem with around one-half of the world’s population still infected. In the image, micrograph of H. pylori bacteria on the surface of a human gastric epithelial cell

    Drug therapies for Helicobacter pylori infections Subscription

    Selecting the most appropriate treatment regimen for patients with Helicobacter pylori.

  • Pharmacy professionals have the opportunity to specialise in a variety of clinical areas

    Specialist roles in hospital pharmacy Subscription

    Pharmacy professionals have the opportunity to specialise in a variety of clinical areas. Eamonn McArdle explores the possibilities.

  • Healthcare-associated infection in England was 6.4% in 2011 and six common infections accounted for over 80% of infections in adults. In the image, a petri dish with a staphylococcus aureus culture

    Healthcare-associated infection: best practice in prevention and control Subscription

    Understand the standard principles and practices of infection control, with a brief overview of initiatives aimed at reducing rates of infection acquired in a healthcare setting.

  • Learning articles of the year: check your knowledge of subjects ranging from ebola to QT syndrome.

    Highlights of CPD and learning in 2014 Subscription

    Try our clinical quiz, taken from this year’s learning articles, and check your knowledge of subjects ranging from Ebola to QT syndrome.

  • New drugs are under development to reduce the use of antibiotics in animals and help slow the rise of antimicrobial resistance in humans

    Strategies to reduce the use of antibiotics in animals Subscription

    New drugs that could eventually replace or reduce the use of antibiotics in animals are in development to help slow the rise of antibiotic resistance.

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