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Antimicrobial stewardship

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  • Research on antimicrobial resistance

    AMR and diagnostics: pointing the way to better infection control Subscription

    Antimicrobial resistance — the ability of previously sensitive microorganisms to resist the effects of an antimicrobial agent — is a growing problem. The World Health Organization has warned that we could be moving into a post-antibiotic era where even minor injuries could lead to life-threatening infections, consequently putting an end to complex surgery and returning us to an era where childbirth is high-risk.

  • Scanning electron micrograph of methicillin-resistant Staphylococcus aureus (MRSA) bacteria

    Antimicrobial therapies for Gram-positive infections Subscription

    Gram-positive bacteria are among the most common human pathogens associated with clinical infections, which range from mild skin infections to sepsis. In an era defined by antimicrobial resistance (AMR) and an increasing drive toward delivering patient care via ambulatory pathways, the paradigm for the management of infections is changing. Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE), the best known cases of ...

  • Micrograph of Acinetobacter baumannii bacteria

    Ceftazidime-avibactam: a novel cephalosporin/β-lactamase inhibitor Subscription

    Over the past decade, infections caused by multidrug-resistant Gram-negative organisms have increased. The limited availability in treatment options for these infections prompted both the UK to create a five-year antimicrobial resistance strategic plan to stimulate the development of new antibiotics, and the Infectious Diseases Society of America to call for ten new antimicrobial agents to be developed by 2020. Ceftazidime-avibactam is a combination of a third-generation ...

  • Scanning electron micrograph (SEM) of tuberculosis (TB) bacteria infecting macrophages

    Fluoroquinolones for treating tuberculosis Subscription

    Tuberculosis (TB) remains a significant global health and socioeconomic challenge. The duration of current anti-TB therapies, the adverse effects of certain anti-TB drugs and the growing problem of drug-resistant TB on an international scale mean that it is imperative for new, effective and safe treatment regimens to be developed. Fluoroquinolones are a class of drugs that have been used in the treatment of TB for several decades. This article provides an overview of the current treatment ...

  • Micrograph of Clostridium difficile bacteria

    Clostridium difficile: diagnosis and treatment update

    There are around 12,000 cases of Clostridium difficile infection (CDI) each year in the UK and during 1999 to 2007, deaths from CDI peaked at around 4,000 per year. This article summarises diagnosis and management, as well as the current therapeutic options for CDI, including faecal microbiota transplant.

  • Collage showing MRSA, research and antibiotics

    New approaches to overcoming antimicrobial resistance Subscription

    As antibiotic resistance continues to threaten the treatment of various infections, researchers are looking for new ways to supplement and in some cases replace failing antimicrobial drugs.

  • Illustration antibiotic destroying bacteria

    Principles of initiating antimicrobial therapy and empiric prescribing Subscription

    Healthcare professionals should be aware of the principles of antimicrobial treatment and the need to reduce inappropriate prescribing to retain the effectiveness of drugs currently available.

  • Helicobacter pylori infections and treatment remain an unsolved problem with around one-half of the world’s population still infected. In the image, micrograph of H. pylori bacteria on the surface of a human gastric epithelial cell

    Drug therapies for Helicobacter pylori infections Subscription

    Selecting the most appropriate treatment regimen for patients with Helicobacter pylori.

  • Pharmacy professionals have the opportunity to specialise in a variety of clinical areas

    Specialist roles in hospital pharmacy Subscription

    Pharmacy professionals have the opportunity to specialise in a variety of clinical areas. Eamonn McArdle explores the possibilities.

  • Healthcare-associated infection in England was 6.4% in 2011 and six common infections accounted for over 80% of infections in adults. In the image, a petri dish with a staphylococcus aureus culture

    Healthcare-associated infection: best practice in prevention and control Subscription

    Understand the standard principles and practices of infection control, with a brief overview of initiatives aimed at reducing rates of infection acquired in a healthcare setting.

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