Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

  • 4 of 6

Figure 1: Neuromodulation for rheumatoid arthritis

Electrical stimulation of the vagus nerve with an implantable bioelectronic device affects splenic T-cells and macrophages to reduce production of tumour necrosis factor (TNF), an inflammatory mediator, leading to reduced rheumatoid arthritis symptoms in some patients. 1) A microregulator stimulates the vagus nerve. The signals sent through the vagus and splenic nerve trigger a reduction in the activation of T cells and macrophages in the spleen 2) There is a reduced production of systemic inflammation mediators and reduced activation of circulating immune cells 3) This leads to decreased inflammation, joint damage and pain

Source  SetPoint