Glenis K Scadding
Glenis K Scadding is honorary consultant physician in allergy and rhinology, Department of Allergy and Medical Rhinology, Royal National Throat Nose and Ear Hospital, 330 Gray’s Inn Road, London.
Allergic rhinitis results from an immunological abnormality in which atopic individuals produce immunoglobulin E (IgE) to allergens (e.g. pollen, house dust mites, animal dander and moulds). IgE activates mast cells, which respond by releasing inflammatory mediators. Histamine stimulates the early symptoms, predominately mucus production, nasal itching and sneezing. Leukotrienes and cytokines attract and activate eosinophils to cause allergic inflammation, which is primarily responsible for