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Pharmacogenomics concept

Pharmacogenomics: an overview

With the NHS working towards the integration of personalised medicine, in particular, aiming for whole-genome sequencing to be standard for specific conditions by 2020, it is important for pharmacists and healthcare professionals to be aware of the principles of pharmacogenomics and its evolving application into clinical practice.

pregnant woman diabetes finger prick lancet blood ss 17

Managing diabetes in women during preconception and pregnancySubscription

Diabetes in pregnancy is associated with risks to the woman and to the developing foetus. Pharmacists and healthcare professionals need to be able to support and educate women who are planning pregnancy and those who are already pregnant to manage their diabetes.

Clinician check a man's foot using a mirror

The diabetic foot

Diabetes-related foot problems are common, and negatively impact patients’ quality of life, so it is important that pharmacists are aware of symptoms and the relevant care pathways for these patients to ensure they receive the best care and education regarding how to manage their condition. Produced in partnership with RB.

Micrograph of non-alcoholic fatty liver (NAFL)

Non-alcoholic fatty liver disease and diabetes: diagnosis, assessment and management

Non-alcoholic fatty liver disease is the term for a range of conditions caused by a build-up of fat in the liver. The condition is thought to be highly prevalent; however, the dearth of symptoms during early disease and the lack of a specific diagnostic test make it difficult to detect and manage at an early stage. This presents a considerable challenge for healthcare professionals.

SEM of activated platelets

Heparin-induced thrombocytopeniaSubscription

Heparin is widely used for thromboprophylaxis or as a treatment in many clinical situations, however, it can cause serious adverse effects. Heparin-induced thrombocytopenia (HIT), an immune-mediated adverse drug reaction, is associated with high morbidity and mortality if undiagnosed.

Xray showing chronic oedema in the lower limb

Chronic oedema: treatment and the impact of prescribed medicinesSubscription

Early diagnosis of lower limb oedema is crucial to prevent early oedema becoming chronic. Pharmacists and other healthcare professionals are ideally placed to identify patients on certain medicines at higher risk of oedema, and should be aware of signs of chronic oedema when assessing patients to allow for prompt referral.

Scanning electron micrograph (SEM) of tuberculosis (TB) bacteria infecting macrophages

Fluoroquinolones for treating tuberculosisSubscription

Tuberculosis (TB) remains a significant global health and socioeconomic challenge. The duration of current anti-TB therapies, the adverse effects of certain anti-TB drugs and the growing problem of drug-resistant TB on an international scale mean that it is imperative for new, effective and safe treatment regimens to be developed. Fluoroquinolones are a class of drugs that have been used in the treatment of TB for several decades. This article provides an overview of the current treatment ...

Action of serotonin reuptake inhibitors

Depression in adults: recognition and management

Pharmacists and healthcare professionals should be able to recognise the symptoms of depression in people who use their services and direct them towards accessing treatment. This article examines how a diagnosis of depression is made, the pharmacological and non-pharmacological treatments available, specific considerations for different patient groups, self-management approaches, and the role of the pharmacy team in managing and supporting patients who have symptoms of depression.

Micrograph of multiple myeloma tumour cells (green) and bone cells (red) growing on a scaffold made of silk protein (purple), designed to resemble bone material

Multiple myeloma: pharmacological management

Although multiple myeloma is currently regarded as being incurable in the majority of patients, the outlook for patients diagnosed with the condition has improved markedly over the last 40 years, with survival rates quadrupling. Significant advances in both treatment and supportive therapies have contributed to these improved outcomes and are discussed in this article.

Micrograph of Clostridium difficile bacteria

Clostridium difficile: diagnosis and treatment update

There are around 12,000 cases of Clostridium difficile infection (CDI) each year in the UK and during 1999 to 2007, deaths from CDI peaked at around 4,000 per year. This article summarises diagnosis and management, as well as the current therapeutic options for CDI, including faecal microbiota transplant.

coloured scanning electron micrograph (SEM) of bacterial blood infection (sepsis) caused by a rod shaped bacterium (blue)

Sepsis: an update on identification and management Subscription

All healthcare professionals, including pharmacists, should be aware of the clinical features and management of sepsis. This article summarises the recent changes in the definition of sepsis in adults, as well as its management.

Testing for blood clotting

How to identify causes of a subtherapeutic INRSubscription

Pharmacists and healthcare professionals are often involved in the management of patients with subtherapeutic international normalised ratios (INRs), the cause of which is important to identify because this will affect decisions and the subsequent management of the patient.

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