Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Respiratory disease

How to help patients optimise their inhaler technique

Examining the impact of sub-optimal inhaler technique and how healthcare professionals can support patients in optimising their technique.

Illustration showing the different types of asthma inhalers: From left, MDI inhaler, turbohaler, autohaler and accuhaler

Source: Illustration by Javier Trigo

Estimates of inhaler errors include up to 90% of patients using pressurised metered dose inhalers (pMDIs). In the image, (left to right) a MDI, Turbohaler, Autohaler and Accuhaler

Asthma and chronic obstructive pulmonary disease (COPD) are common conditions in the UK and inhaled medications are the cornerstone of their management[1]. Good inhaler technique is essential to maximise the benefits of these medications and improve outcomes for the patient. This article considers the impact of sub-optimal inhaler technique and how healthcare professionals can support patients in optimising their technique.

The goal of asthma treatment is for patients to be symptom free and to be able to lead a normal, active life. More information on asthma, its diagnosis, treatment and management has been covered in previous articles[2],[3]. The diagnosis, treatment and management of COPD has also been covered in previous articles[4],[5]. In England and Wales, 45 million prescriptions for inhalers were issued in 2011 at a cost of around £900m[1].

If used correctly, inhalers deliver a smaller effective amount of the drug directly to the site of action in the lungs, with a faster onset of effect and with reduced systemic availability that minimises adverse effects (when compared with systemic administration). Despite this being the preferred method of medication delivery to the lungs, evidence suggests that many patients are unable to use their inhalers effectively[6]. Although study results vary, estimates of inhaler errors include up to 90% of patients using pressurised metered dose inhalers (pMDIs)[6],[7],[8] and up to 54% of patients using dry powder inhalers (DPIs)[6],[9]. Inadequate inhaler technique lowers drug deposition to the lungs, wastes medication and may lead to poor disease control, reduced quality of life, increased emergency hospital admissions and higher treatment costs[10],[11]. In 2014, the National Review of Asthma Deaths (NRAD) reported that misunderstanding and misuse of inhalers was thought to have contributed to a significant number of the 195 asthma deaths during 2012[12]. According to the NRAD report, only 49% of patients reviewed in primary care had their inhaler technique checked in the year before their death[12]. Furthermore, 17% of patients admitted to hospital (n=83) did not have documented evidence that their inhaler technique had been checked during their admission[12].

There is increasing evidence to suggest that correct inhaler technique plays an important role in improving medicine adherence[13],[14],[15], clinical outcomes[14],[15], quality of life[16] and use of healthcare resources[14]. The National Institute for Health and Care Excellence (NICE), England’s health technology assessment body, guideline for patients with COPD[17] and the British Thoracic Society guideline for asthma[18], both recommend that prior to prescribing a new inhaler, the patient should receive training and education in the use of the device. Both sets of guidelines also advise that inhaler technique should be regularly assessed at each clinic visit[17],[18]. However, recent data suggests that only 7% of healthcare professionals could demonstrate all the correct steps for using a MDI[19].

Correct technique depends on the inhaler type, therefore, patients need to understand the right steps for their own inhaler. It is a good idea for healthcare professionals to learn how to correctly use each inhaler device and to be aware of common errors so they can confidently demonstrate this to patients.

Types of inhaler device

Broadly speaking, there are two classes of inhaler devices[6]: aerosols, which are either solutions containing medications or suspensions of solid particles in a gas, generated from devices (e.g. pMDIs or breath-actuated pMDI); and DPI delivery devices containing drugs in powdered formulation that have been milled to produce particles in the respirable range. DPI delivery devices allow the particles to be separated by the energy created by the patient’s own inspiratory flow, compared with the pMDI where the device itself generates the energy[20]. For further information, see ‘Table 1: Advantages and disadvantages of the main inhaler types’. See Figures 1–5 for the range of devices currently available.

Table 1: Advantages and disadvantages of main inhaler types
Reproduced with permission from[21].
 AdvantagesDisadvantages
Metered dose inhalers (MDIs)
  • Portable and compact
  • Treatment time is short
  • No drug preparation required
  • No contamination of contents
  • Dose-dose reproducibility high
  • Coordination of breathing and actuation needed
  • Device actuation required 
  • High pharangeal deposition
  • Upper limit to unit dose content
  • Remaining doses difficult to determine
  • Potential for abuse
  • Not all medications available
MDI + holding chamber, reverse-flow spacer or spacer
  • Reduces need for patient co-ordination
  • Reduces pharyngeal deposition
  • Inhalation can be more complex for some patients
  • Can reduce dose available if not used properly
  • More expensive than MDI alone
  • Less portable than MDI alone
  • Integral actuator devices may alter aerosol properties compared to native actuator
Dry powder inhalers (DPI)
  • Breath actuated
  • Less patient coordination required
  • Propellant not required
  • Small and portable
  • Short treatment time
  • Dose counters in most newer designs
  • May require moderate to high inspiratory flow
  • Some units are single dose
  • Can result in high pharyngeal deposition
  • Not all medications available

What are the common problems with inhaler technique and what are their solutions?

Despite the development of several new types of inhaler device over the past 40 years, there has been no sustained improvement in how patients use them[6]. Initiatives trying to improve patient use of inhalers have included: regular training programmes for patients and healthcare professionals; printed instructional material and videos; measures and devices to make inhalation easier (e.g. the development of a breath-actuated MDI and the attachment of a holding spacer to the MDI); and the design of various DPIs. However, a recent systematic review of inhaler technique concludes that incorrect inhaler technique is unacceptably frequent and has not improved over the past 40 years, indicating an urgent need for new approaches to education and drug delivery[6].

All types of inhaler devices have similar efficacy when tested under strict clinical trial conditions[22], however, in the real-life setting of clinical practice, a perfect inhaler does not exist; each has its advantages and limitations (see table 1). For the individual patient, inhalers should not be viewed as equivalent, and device type must become an important variable to consider when planning optimal treatment. Ensuring effective inhalation and drug delivery to the target site depends on many factors, which ultimately impact on patients’ response to treatment. In practice, the choice of inhaler device should not only take device-related aspects (e.g. aerosol velocity) into consideration, but also patient factors (e.g. inhalation flow, dexterity, cognition and preferences). With all inhaler types, error rates increase with age and the severity of airflow obstruction[23],[24].

Incorrect inhaler technique is common, regardless of the type of device prescribed. Patients may be given different inhaler types, receive minimal training (if any) and sometimes receive incorrect training on how to use the device. Therefore, it is important to understand the differences between these two types of inhalers, especially regarding how fast the patient inhales (inspiratory flow)[25],[26],[27]. The concurrent use of multiple types of inhaler devices with different techniques can confuse patients. Ideally, patients should be prescribed one type of device or, failing that, all aerosols or dry-powder devices so that the same inhalation technique can be used.

Examples of common inhaler technique errors and recommendations for improvement are described in ‘Table 2: Common inhaler technique errors and suggested solutions’.

Table 2: Common inhaler technique errors and suggested solutions  
Common errorExplanation and suggested solutions
Not shaking an aerosol inhaler device before useNot shaking the canister properly may lead to inconsistent dosing and poorly functioning inhalers. Shake all inhalers; most dry powder inhalers (DPI) do not need shaking before use.
Not priming the aerosol inhaler deviceAerosol inhalers require priming (to check that the spray is functioning) before using for the first time, or if they have not been used for a while (usually five to seven days).
Not breathing out before inhalingBreathing out fully (or as much as is comfortable) reduces the amount of air in the airways and increases the available space for air from the next breath. The result is a deeper than normal inhalation, maximising the opportunity to carry the drug to the site of action.
Incorrect positioning of inhaler device

Patients should be instructed not to hold a DPI with the mouthpiece pointing downwards during, or after loading, a dose, as the drug can escape. It should be kept horizontal or upright.

The patient should keep their chin up or head slightly tilted back when using the inhaler. It should be placed correctly in the mouth and the lips should form a tight seal over the mouthpiece. 

Incorrect coordination of pressured metered dose inhaler (pMDI) actuation with inspirationTo deliver the medication to the lungs from a pMDI, the patient must coordinate breathing in with pressing the canister.
Delay in inhaling drug through a holding spacer device (a device when combined with a pMDI helps to improve aerosol delivery)The medication stays suspended in the spacer for a short time only, so if patients fail to take each dose without delay immediately after loading the spacer, a proportion of the dose is deposited on to the inner surface of the spacer and is therefore lost.
Incorrect inspiratory flow rate: breathing in either too fast or too slowThe total lung deposition of an inhaled drug is strongly affected by the speed of inhalation.
  • Aerosol devices, such as pMDIs, require a slow and steady inhalation to increase lung deposition. When the patient inhales, the drug particles will follow the path that the air takes until a change in direction occurs, at which time the particles will try to continue to move in the same direction they were travelling. Too fast an inhalation will increase the velocity of the drug particles, thus increasing inertial impaction at the points where the airways change direction significantly (particularly at the throat and where the main airways of the lung branch out). Think about this as a sharp bend at the end of a straight piece of road: any vehicle that is travelling too fast will crash.
  • The aerosol device itself generates its own propellant and releases the particles at speed, and so a slower inhalation rate is required to guide the drug to the site of action. Furthermore, the pMDI is easy to inhale through as it has little resistance to airflow, which means it is relatively easy for patients to inhale too fast.
  • DPIs require a quick and deep inhalation to generate a large internal turbulent force to break up the formulation to optimise the particle size and lung deposition. The inhalation should, therefore, be forceful from the start and failure to achieve this high internal force increases the likelihood of the dose impacting in the mouth and throat. DPI devices have a high resistance to airflow, which limits the inhalation flow rate through the device and, consequently, patients using a DPI need to apply greater effort to generate the necessary flow for optimum drug delivery.
Not holding your breath after inhalationThe ‘breath hold’ increases lung deposition through the process of sedimentation. By keeping the air still for a few seconds, a greater number of particles will sediment on to the receptor sites because of gravity.
Multiple actuations without waiting in between actuationsVery rapid actuations can reduce the dose delivered per actuation.
Using an empty inhalerPatients frequently fail to detect when the inhaler is empty, particularly when using reliever aerosol devices.
Poor maintenance of inhaler or spacer device Spacers should be reviewed every 6–12 months to check that the structure is intact (e.g. no cracks), the outer casing is clean and the valve is functioning.

How can healthcare professionals talk to patients effectively about inhaler technique?

Training of patients by healthcare professionals has been shown to be an effective means of improving technique[28], but it needs to be repeated at intervals, and it is essential that those providing the training are themselves able to demonstrate the correct technique.

A recent study suggested that up to 25% of patients have not received any verbal instruction for the use of their prescribed inhaler[10]. When given, instruction is often rushed, poor quality and not reinforced. Only an estimated 11% of patients receive follow-up assessment and education on their inhaler technique[29]. Inhaler technique has been found to deteriorate over time (possibly after as little as two to three months)[30], so instruction needs to be repeated at regular intervals. In an Australian study, 75% patients using an inhaler for an average of two to three years reported that they were using their inhaler correctly but, on objective checking, only 10% demonstrated correct technique[31].

Figures 1–5 provide a summary of the techniques for the commonly used inhaler devices, and common errors with patient technique, that healthcare professionals can use as a guide before training patients.

Step by step guide showing how to use an MDI inhaler

Figure 1. How to use a metered dose inhaler (MDI)

Illustration by Javier Trigo

1: Cap should be removed and inhaler shaken to ensure consistent delivery of dose. Device should be primed if patient is using for the first time, or if not used for a while.
2: Patient should breathe out fully.
3: Patient should breathe in slowly and steadily and press down on the inhaler device.
4: On inhalation, the patient should hold their breath for a count of ten.
5: Patient should slowly breathe out, repeat dose (if applicable), and replace mouthpiece cover. Clean device if necessary after use.

Common errors in technique made by patients:

  • Not shaking the aerosol inhaler before use
  • Not priming the aerosol inhaler before first use
  • Failing to detect an empty inhaler before use
  • Failing to breathe out fully before inhaling
  • Incorrect coordination of MDI and pMDI actuation with inspiration
  • Incorrect inspiration flow rate (breathing in too fast or too slow)
  • Failing to hold breath after inhalation

For solutions to these common errors, please see table 2.

Step by step guide showing how to use an MDI inhaler with spacer

Figure 2. How to use a metered dose inhaler (MDI) with spacer

Illustration by Javier Trigo

1: Cap should be removed and the patient should check to see if the mouthpiece is clean. Inhaler should be shaken to ensure consistent delivery of dose. Device should be primed if patient is using for the first time, or if not used for a while.
2: The inhaler mouthpiece should be inserted into the end of the spacer device.
3: Patient should breathe in, and then breathe out fully.
4: The inhaler and spacer device should be held between the index finger and thumb. The spacer mouthpiece should be placed in the mouth, above the tongue. The patient should close their lips around the spacer device.
5: The patient should tilt their head back slightly toward the ceiling. The top of the inhaler device should be pressed to release a single dose of medicine. The patient should slowly breathe in all of the air and hold breath for ten seconds.
6: Patient should open mouth, remove spacer device and breathe out slowly. Patients could also use the tidal breathing technique, where they breathe slowly and steadily in and out four to five times. 

Common errors in technique made by patients:

  • Not shaking the aerosol inhaler before use
  • Not priming the aerosol inhaler before first use
  • Failing to detect an empty inhaler before use
  • Failing to breathe out fully before inhaling
  • Delay in inhaling drug through a holding spacer device
  • Incorrect inspiration flow rate (breathing in too fast or too slow)
  • Failing to hold breath after inhalation
  • Poor maintenance of inhaler or spacer device

For solutions to these common errors, please see table 2.

Illustration showing how to use an accuhaler

Figure 3: How to use an Accuhaler

Illustration by Javier Trigo

1: Holding the device horizontal or upright, the patient should open the inhaler by moving sliding lever in the correct direction.
2: Patient should breathe out fully but not into the Accuhaler.
3: Patient should place the inhaler device in the mouth, with the lips forming a tight seal over the mouthpiece, before breathing in quickly and deeply through the inhaler device.
4: On inhalation, the patient should hold their breath for a count of ten.
5: Patient should slowly breathe out.
6: Inhaler should be closed correctly by moving sliding lever in the correct direction. The inhaler should be cleaned as necessary.

Common errors in technique made by patients:

  • Failing to breathe out fully before inhaling
  • Incorrect positioning/holding of device
  • Not breathing in quickly and deeply at the start of inhalation
  • Failing to hold breath after inhalation
  • Poor maintenance of inhaler

For solutions to these common errors, please see table 2.

Step by step guide showing how a patient should use a turbohaler

Figure 4: How to use a turbohaler

Source: Illustrations by Javier Trigo

1: The patient should unscrew the cap (turning anticlockwise) and remove. Holding the inhaler upright, the dose can be loaded by turning the coloured base to the right, as far as it will go.
2: Then twist it back to the left until it clicks. It is now loaded.
3: The patient should breathe out gently, away from the device. Holding the device without covering the air inlets, the tip of the mouthpiece should be placed between the lips and a good seal made.
4: The patient should breathe in quickly and deeply and hold their breath for 5–10 seconds. Remove the device before breathing out fully. Clean the device as necessary, replace the cap and screw it shut.

Common errors in technique made by patients:

  • Incorrect positioning/holding of the device
  • Incorrect inspiration flow rate (breathing in too fast or too slow)
  • Poor maintenance of inhaler

For solutions to these common errors, please see table 2.

It is a good idea for healthcare professionals to learn how to correctly use each inhaler device (see additional resources for useful videos) and to be aware of common errors (see Table 2 and Figures 1–5), so they can confidently demonstrate this to patients. Healthcare professionals should also learn the rationale for each step of the instructions, so they can clearly explain its importance to patients during counselling (see ‘Box 1: How to engage with patients to confirm inhaler technique’ and ’Box 2: Inhaler technique checklist’).

Box 1: How to engage with patients to confirm inhaler technique

  • Introduce yourself to the patient;
  • Ask the patient if you can discuss their inhaler treatment with them. Do not ask “Can you use your inhaler?” It is better to say “Can you show me how you use your inhaler so that we can see if we can improve the amount of medicine getting into your lungs?” Do not rely on the patient’s assurance that they know how to use their inhaler; most are unaware that their inhaler technique could be improved;
  • It is worth understanding what the patient knows about their lung condition. Educating patients in correct inhaler use may also improve adherence to their treatments;
  • Discuss the inhaler with the patient, explaining what medicine it contains and how it should help their lung condition;
  • Describe the steps of using the inhaler device (see Box 2 and Figures 1-5);
  • Once you have described the steps, show the patient how to do it yourself;
  • After you have demonstrated the optimal technique, ask the patient to show you how they would use the inhaler. Check they are doing it correctly and, if needed, explain how they can improve their technique. Non-availability of ample placebo devices can be a barrier to effective education. If a patient has their own inhalers, then an extra dose of these could be given if it is thought unlikely to cause undue harm;
  • Ensure the patient knows how to keep their inhaler clean and in good working order. As every inhaler is different, ask the person to follow the manufacturer’s instructions. Also, make sure your patient knows how to recognise that their inhaler is empty or nearly empty;
  • Ask the patient if they have any questions or concerns about their medicine and the steps to optimise the delivery to their lungs;
  • Repeat instruction regularly. Inhaler technique must be rechecked and education must be regularly reinforced in order to maintain optimal drug delivery.

Box 2: Inhaler technique reminder checklist

  1. Prepare the device (e.g. remove the mouthpiece cover, open the device, hold the inhaler upright).
  2. Prepare the dose (e.g. shake all aerosols and load dose for DPIs).
  3. Breathe out gently as far as is comfortable (not into inhalers).
  4. Put the mouthpiece in the mouth and close the lips around it.
  5. Breathe in:
    • Check co-ordination of breathing and actuation of MDI
    • Think about the type of inhaler device - is it an aerosol device or DPI?
      • Breathe in slowly and steadily for all aerosol devices (including through a spacer device).
      • Breathe in quickly and deeply for all DPIs
  6. Remove inhaler from the mouth and hold breath for ten seconds
  7. Repeat dose (if applicable), replace mouthpiece cover or close device.

Additional resources:

Anna Murphy is consultant respiratory pharmacist, University Hospitals of Leicester NHS Trust and honorary visiting professor, De Montfort school of pharmacy, Leicester.

 

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2016.20201442

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Patient Care in Community Practice

    Patient Care in Community Practice

    Patient Care in Community Practice is a unique, practical guide for healthcare professionals or carers. Covers a range of non-medicinal products suitable for use at home.

    £21.00Buy now
  • Drugs in Use

    Drugs in Use

    Optimise drug therapy for your patients. These case studies help you bridge the gap between theoretical medicines knowledge and practical applications.

    £42.00Buy now
  • Healthcare Communication

    Healthcare Communication

    Healthcare Communication is an interactive and engaging guide for healthcare professionals. It supports you in establishing rewarding professional relationships.

    £32.00Buy now
  • International Research in Healthcare

    International Research in Healthcare

    Guidance for students or researchers undertaking a multi-centre research project in health services, medicines use and professional practice.

    £37.00Buy now
  • Stockley's Drug Interactions Pocket Companion

    Stockley's Drug Interactions Pocket Companion

    The 2016 pocket guide to drug interactions and their management, for the busy healthcare professional.

    £29.95Buy now
  • BNF for Children (BNFC) 2017-2018

    BNF for Children (BNFC) 2017-2018

    The BNFC contains essential practical information for all healthcare professionals involved in prescribing, dispensing, monitoring and administration of medicines to children.

    £55.00Buy now

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Illustration showing the different types of asthma inhalers: From left, MDI inhaler, turbohaler, autohaler and accuhaler
  • Step by step guide showing how to use an MDI inhaler
  • Step by step guide showing how to use an MDI inhaler with spacer
  • Illustration showing how to use an accuhaler
  • Step by step guide showing how a patient should use a turbohaler

Jobs you might like

See more jobs

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.