Gentamicin: dose regimens and monitoring Subscription
How to calculate the correct dose of gentamicin and monitor patients to prevent toxicity.
Mixing medicines: how to ensure patient safety Subscription
Incompatibility poses a constant risk when mixing medicines but it can be avoided by understanding the chemical reactions taking place.
Liver impairment: ensuring medicines safety Subscription
How liver disease can affect absorption and excretion and the clinical consequences for common medicines.
Tizanidine interactions Subscription
Careful titration of the skeletal muscle relaxant tizanidine is required to avoid dose-related hypotension, and its serum levels can be increased by drugs that inhibit CYP1A2.
Theophylline interactions Subscription
Can someone start nicotine replacement therapy while taking theophylline to manage COPD?
Is the most suitable NSAID being used? Subscription
A case study from the BNF highlights issues to consider when prescribing or supplying non-steroidal anti-inflammatory drugs
Let’s recap on gliptin DPP-4 inhibitors Subscription
There are currently four agents that inhibit dipeptidylpeptidase-4 available in the UK. Commonly called “gliptins”, they are a relatively new class of drugs. Linagliptin (Trajenta) is still included in the Medicines and Healthcare products Regulatory Agency black triangle scheme, so is being intensively monitored. Sitagliptin (Januvia), saxagliptin (Onglyza) and vildagliptin ...
Before you rush to your nearest BNF to look up Obecalp, it is merely the word “placebo” spelt backwards, and an item that is reported to have been ordered on prescriptions. Use of placebos hit the news last month. Headlines such as “Most family doctors have given a patient a placebo drug”1 were referring to a study published in PLOS ...
Let’s recap on antiplatelet agents Subscription
The new medicine service in England can be provided to any patient starting antiplatelet therapy. Unlike diuretics, calcium channel blockers and so forth, there is no requirement that the medicine is being used to treat one specific condition.
What’s this latest fuss about aspirin? Subscription
Aspirin has had its fair share of column inches in the medical and pharmaceutical press over recent months. In January this year, a meta analysis confirmed that it should not be used for the primary prevention of cardiovascular events. However, within three lunar cycles, we were told that it could prevent cancer. So, in light of this latest entry to the aspirin evidence ...