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Osteoporosis: moving beyond bisphosphonates

Infographic showing burden, disorder and treatment of osteoporosis

Bisphosphonates are the mainstay of osteoporosis treatment but as more is elucidated about the underlying pathology of the condition, new drug targets are being investigated.

See the full infographic here

Infographic showing the prevalence and burden of osteoporosis

Prevalence and burden of osteoporosis

Osteoporosis is a relatively common disease, affecting more women than men. Disease burden is significant, particularly in older individuals, with osteoporotic fractures leading to reduced function and loss of independence.

Infographic showing the complexities of osteoporosis

A complex disorder

Osteoporosis is a complex disorder characterised by an imbalance in the bone remodelling process, which is governed by intricate interactions between various hormones, cytokines and a novel regulatory system. This imbalance leads to lower bone density, which culminates in bone fracture.

Treatment targets of osteoporosis

Treatment targets

Osteoporosis treatments target different processes within the bone remodelling cycle.

Graph showing treatments for osteoporosis and bisphosphonate usage

Osteoporosis treatments

Licensed treatments for osteoporosis reduce the risk of fractures, but are associated with various adverse effects — the risks and benefits should be weighed up for each patient. Several novel treatments are in the development pipeline.

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2016.20201978

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  • Infographic showing the prevalence and burden of osteoporosis
  • Infographic showing the complexities of osteoporosis
  • Treatment targets of osteoporosis
  • Graph showing treatments for osteoporosis and bisphosphonate usage

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