Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.


Subscribe or Register

Existing user? Login

Medicines highlighted as risk factor in AKI guideline

By News team

Healthcare professionals have access to a new clinical guideline to help them detect and prevent acute kidney injury (AKI), which is seen in up to 18 per cent of all people admitted to hospital.

The guideline, published today (28 August 2013) by the National Institute for Health and Care Excellence, recommends that healthcare professionals investigate for AKI by measuring serum creatinine levels in people with acute illness if one of a number of risk factors is present. One of the factors noted is that patients are using drugs with nephrotoxic potential within the past week, especially if the patient is hypovolaemic (has a reduced circulating blood volume).

These drugs include non-steroidal anti-inflammatory drugs (NSAIDs), aminoglycosides, angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists and diuretics.

Other factors noted, include: the patient has heart failure, liver failure, diabetes, a history of acute kidney injury, reduced urine output, neurological impairment, hypovolaemia, sepsis, or is aged 65 years or over.

Coral Hulse, a nurse consultant at the Mid-Cheshire Hospitals who helped develop the guideline, said: "Monitoring fluid intake and how much urine is passed is vital in the war against acute kidney injury as is monitoring the medication the patient takes and checking results as soon as they are available."

NICE estimates that around 12,000 cases of AKI are partially or fully preventable.

Earlier this year, a BMJ study found that patients taking a high-potency statin compared with patients taking a low-potency statin have an increased risk of admission to hospital for AKI (PJ 2013;290:326).

Read more about the management of AKI here.

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2013.11124836

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Pharmacy Registration Assessment Questions

    Pharmacy Registration Assessment Questions

    Pharmacy Registration Assessment Questions features over 400 closed book and calculation questions. With the registration exam having gone through a complete transformation in 2016, this volume has been developed around the new General Pharmaceutical Council (GPhC) guidelines.

    £32.00Buy now
  • Stockley's Herbal Medicines Interactions

    Stockley's Herbal Medicines Interactions

    An invaluable reference for interactions of conventional medicines with herbal medicines, dietary supplements and nutraceuticals.

    £80.00Buy now
  • Popular Medicines

    Popular Medicines

    An illustrated history of some of the most popular branded medicines. Includes colourful historical adverts and details of the medicine's formula and intended purpose.

    £21.00Buy now
  • Strategic Medicines Management

    Strategic Medicines Management

    A practical guide to influencing the availability of medicines, and policies of their use. Focuses on the strategic elements of medicines management.

    £32.00Buy now
  • Dale and Appelbe's Pharmacy and Medicines Law

    Dale and Appelbe's Pharmacy and Medicines Law

    This new edition of Dale and Appelbe's Pharmacy and Medicines Law is the definitive guide to law and ethics for pharmacy practice in the UK. It covers law and professional regulation and is firmly established as the definitive student textbook and reference work on this subject in the UK. Fully updated to include changes to pharmacy laws and regulation.

    £55.00Buy now
  • Medicines Use Reviews

    Medicines Use Reviews

    Conduct successful Medicines Use Reviews (MURs) with this comprehensive book. Contains evidence-based information, tips and guidance.

    £26.00Buy now

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Graphic image of a kidney (Skypixel/

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.