Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.


Subscribe or Register

Existing user? Login


Alendronate might help protect against hip fractures

Patients treated with prednisolone are likely to benefit from receiving the osteoporosis treatment alendronate, but further research is needed.

Xray of hip fracture


Study results support the use of alendronate in elderly patients receiving medium to high doses of prednisolone to reduce the risk of hip fracture

Glucocorticoids are associated with a dose-dependent increased risk of hip fractures, but there is not sufficient evidence to show whether the osteoporosis treatment alendronate can reduce this.

In a retrospective cohort study, researchers analysed Swedish data on 1,802 patients aged 65 years and over who received a prescription for alendronate while receiving prednisolone for at least three months, compared with 1,802 matched controls who received similar prednisolone treatment courses without alendronate.

After median follow-up of 1.32 years, there were 27 hip fractures in the alendronate group compared with 73 in the prednisolone-only group. In multivariate analysis, this equated to a 65% reduced risk of hip fracture with alendronate.

Reporting in the Journal of the American Medical Association (online, 11 July 2017), the team says the findings support the use of alendronate in elderly patients receiving medium to high doses of prednisolone, but they are limited by the small number of events and observational study design[1].

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20203332

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Xray of hip fracture

Jobs you might like

See more jobs

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.