Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Vaccination

Anti-PCSK9 vaccine shows cholesterol-lowering potential in a mouse model

PCSK9 has recently emerged as a promising vaccine target for the effective and economic treatment of hypercholesterolaemia and atherosclerosis.

The newest class of cholesterol-lowering drugs to emerge are proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, such as alirocumab and evolocumab. However, these monoclonal antibodies are expensive and need repeated administration.

In a recent paper, researchers explored the efficacy of a vaccine, called AT04A, designed to trigger production of antibodies against PCSK9 in mouse models of coronary heart disease.

They found that, after 18 weeks, AT04A-vaccinated mice being fed a western-type diet had around 50% lower total cholesterol (−53%, P<0.001) and significantly reduced low-density lipoprotein cholesterol (LDL-C) levels compared with controls. Markers of blood vessel inflammation were also significantly reduced, as well as atherosclerotic lesion areas (−64%, P=0.004).

Reporting in the European Heart Journal[1] (19 June 2017), the researchers say AT04A could be a cost-effective and sustainable approach to lowering LDL-C levels, and it is currently being tested in a phase I clinical trial.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20203111

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • 3D structure of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.