Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Pain management

Antioxidant successfully relieves chemotherapy-induced neuropathic pain

Researchers studied the effects of melatonin on mitochondrial damage and neuropathic pain after chemotherapy.

Chemotherapy-induced neuropathic pain is a common side effect of cancer treatment and can be severe enough to require dose reduction or treatment cessation.

Researchers investigated the potential of melatonin, a potent antioxidant, to reduce mitochondrial damage and neuropathic pain resulting from the chemotherapy drug paclitaxel.

In vitro, paclitaxel was observed to reduce mitochondrial membrane potential and metabolic activity by 50%; however, these effects were prevented with the addition of melatonin. Treatment with melatonin did not inhibit the cytotoxic action of paclitaxel in two relevant cancer lines.  

In a rat model, pre-treatment with oral melatonin administered in drinking water was protective. It limited the development of mechanical hypersensitivity in male and female animals by 50% and 41% respectively. An additive effect was found when melatonin was given with duloxetine.

Melatonin is a potential treatment to limit the development of painful neuropathy resulting from chemotherapy treatment, the researchers concluded in the Journal of Pineal Research (22 September 2017)[1]

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20203779

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Patient receives chemotherapy

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.