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Infectious diseases

Cholesterol-lowering therapies could be used against typhoid

Repurposing cholesterol-lowering drugs could be a potential treatment for typhoid.

Coloured SEM of Salmonella Typhi (S. Typhi) bacteria

Source: CDC / Janice Haney Carr

Researchers carried out a genome-wide association study to identify genetic variation linked to the susceptibility of cells to invasion by the typhoid fever pathogen Salmonella enterica serovar Typhi

There are around 20 million cases of typhoid fever each year but differences in genetic susceptibility to the infection are only just being explored.

In a study in PNAS (online, 21 August 2017), researchers carried out a genome-wide association study to identify genetic variation linked to the susceptibility of cells to invasion by the typhoid fever pathogen Salmonella enterica serovar Typhi (S. Typhi)[1].

They found that a variant within the VAC14 gene, which is involved in lipid regulation, increased susceptibility to infection because higher cholesterol levels in the plasma membrane enabled pathogen docking and invasion. And in zebrafish, they showed that the cholesterol-lowering drug ezetimibe was able to lower the rate of S. Typhi invasion.

The team said the results indicated that repurposing cholesterol-lowering drugs could have potential for the prophylaxis or treatment of typhoid fever.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20203808

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Supplementary images

  • Coloured SEM of Salmonella Typhi (S. Typhi) bacteria

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