Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Hypersensitivity and allergy

Combined oral immunotherapy shows lasting effect against peanut allergy four years later

In a report of the long-term outcomes of probiotics plus peanut oral immunotherapy, more than half of study participants were able to continue eating peanuts up to four years later.

Peanuts

Source: Shutterstock.com

In a placebo-controlled, trial researchers assessed the efficacy of probiotic and peanut oral immunotherapy for patients with a peanut allergy.

Much attention has been paid to the potential of oral immunotherapy to treat food allergies. However, little is known about its long-term effects.

In a study in the Lancet Child & Adolescent Health (online, 15 August 2017), researchers followed up 56 people who had taken part in a placebo-controlled randomised trial of combined probiotic and peanut oral immunotherapy (PPOIT) for peanut allergy after a mean of 4.2 years[1].

They found that 16 (67%) of 24 participants who received PPOIT were still eating peanuts compared with only one (4%) of participants who received placebo. And following a food challenge, seven (58%) of 12 immunotherapy-treated participants showed sustained unresponsiveness at eight weeks compared with only 1 (7%) of 15 participants from the placebo group.

The researchers say the findings support the long-term clinical benefit of combined oral immunotherapy for peanut allergy and suggest that sustained unresponsiveness is a realistic goal for food allergy treatment.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20203684

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Integrated Pharmacy Case Studies

    Integrated Pharmacy Case Studies

    Over 90 case studies based on real life patient-care scenarios. Each case includes learning outcomes and references.

    £42.00Buy now
  • Introduction to Clinical Pharmaceutics (An)

    Introduction to Clinical Pharmaceutics (An)

    This unique textbook covers the role of basic pharmaceutics in clinical outcomes and in explaining the behaviour of medicines in the body.

    £26.00Buy now
  • Pharmacy Case Studies

    Pharmacy Case Studies

    Understand the application of therapeutics in clinical practice with Pharmacy Case Studies. This book helps you to demonstrate the knowledge gained during your studies.

    £32.00Buy now
  • Disease Management

    Disease Management

    Disease Management covers the diseases commonly encountered in primary care by system, with common therapeutic issues. Includes case studies and self-assessment sections.

    £52.00Buy now
  • Introduction to Pharmaceutical Calculations

    Introduction to Pharmaceutical Calculations

    Introduction to Pharmaceutical Calculations is an essential study aid for pharmacy students. The book contains worked examples and sample questions and answers.

    £32.00Buy now
  • Drugs in Use

    Drugs in Use

    Optimise drug therapy for your patients. These case studies help you bridge the gap between theoretical medicines knowledge and practical applications.

    £42.00Buy now

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Peanuts

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.