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Hypersensitivity and allergy

Combined oral immunotherapy shows lasting effect against peanut allergy four years later

In a report of the long-term outcomes of probiotics plus peanut oral immunotherapy, more than half of study participants were able to continue eating peanuts up to four years later.



In a placebo-controlled, trial researchers assessed the efficacy of probiotic and peanut oral immunotherapy for patients with a peanut allergy.

Much attention has been paid to the potential of oral immunotherapy to treat food allergies. However, little is known about its long-term effects.

In a study in the Lancet Child & Adolescent Health (online, 15 August 2017), researchers followed up 56 people who had taken part in a placebo-controlled randomised trial of combined probiotic and peanut oral immunotherapy (PPOIT) for peanut allergy after a mean of 4.2 years[1].

They found that 16 (67%) of 24 participants who received PPOIT were still eating peanuts compared with only one (4%) of participants who received placebo. And following a food challenge, seven (58%) of 12 immunotherapy-treated participants showed sustained unresponsiveness at eight weeks compared with only 1 (7%) of 15 participants from the placebo group.

The researchers say the findings support the long-term clinical benefit of combined oral immunotherapy for peanut allergy and suggest that sustained unresponsiveness is a realistic goal for food allergy treatment.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20203684

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