Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.


Subscribe or Register

Existing user? Login


Dagibatran carries reduced fracture risk compared with warfarin

Among patients with nonvalvular atrial fibrillation, study data show the use of dabigatran rather than warfarin was associated with a lower risk of osteoporotic fracture.

Xray of a femur with a fracture from osteoporosis

Source: Medical Photo NHS Lothian / Science Photo Library

Researchers found the risk of osteoporotic fracture was significantly lower among dabigatran users than warfarin users.

Warfarin has been associated with increased risk of osteoporotic fractures but it has been suggested that dabigatran, which has a different mode of action, might not carry the same risk.

To explore, researchers studied data from a Hong Kong hospital taken from patients with nonvalvular atrial fibrillation, including 3,268 new dabigatran users which were matched to 4,884 new warfarin users.

During a mean follow-up of 501 days, the risk of osteoporotic fracture was significantly lower among dabigatran users than warfarin users (0.7 vs 1.1 per 100 person-years). However, the association with lower risk was only statistically significant for patients with a history of fractures and/or falls (1.6 vs 3.6 per 100 person-years) but not for those without (0.6 vs 0.7 per 100 person years).

Reporting in JAMA[1] (online, 21 March 2017), the researchers suggest that patients could be screened for osteoporotic risk to inform anticoagulant choice, but the findings warrant further investigation.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20202567

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Xray of a femur with a fracture from osteoporosis

Jobs you might like

See more jobs

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.