Disposable diabetes patch measures sweat glucose and delivers metformin
Wearable patch successfully delivered metformin under the skin of mice and reduced blood glucose levels, offering a system researchers say could be used in clinical settings as a treatment for diabetes.
Source: Courtesy of Hyunjae Lee and Changyeong Song
The ongoing need to check insulin levels via blood collection and administer insulin injections is a barrier to effective diabetes management.
Therefore, researchers from South Korea have developed a potential alternative approach in the form of a wearable and disposable patch that non-invasively measures sweat glucose and delivers medication via microneedles.
In a paper published in Science Advances (8 March 2017), the researchers discovered that sweat glucose levels recorded by the patch correlated well with blood glucose measured with a commercial glucose meter. They also tested the microneedle drug delivery mechanism in mice, where metformin was successfully delivered under the skin and resulted in dose-dependent blood-glucose reduction.
The researchers say that with further research and development, the system could be pursued in clinical settings as a painless, stress-free way to treat diabetes.
Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20202547
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