Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Parasitic diseases

Live malaria vaccine effective in human trial

Injecting healthy volunteers with sporozoites from malaria parasite Plasmodium falciparum offered successful protection against injected malaria ten weeks after final dose.

Micrograph of the plasmodium falciparum virus

Source: Shutterstock.com

Researchers explored whether injecting healthy volunteers with sporozoites from the malaria parasite Plasmodium falciparum could result in immunity to infection

There is currently no licensed vaccine against malaria, a disease that affects over 200 million people per year.

In a paper published in Nature[1] (online, 15 February 2017), a team of researchers explored whether injecting healthy volunteers with sporozoites from the malaria parasite Plasmodium falciparum, could result in immunity to infection. Volunteers also received the malaria prophylactic chloroquine throughout.

The researchers found that the greatest immune response was seen in those who received the maximum dosage at each of the three monthly vaccinations. All of these nine volunteers were protected against infection when exposed to an injected malaria challenge ten weeks after the final dose. None of the 13 control volunteers were protected.

The researchers say that the results show the vaccine’s potential, most importantly for use in a mass drug administration and vaccination programme, but further research is needed to optimise the administration regimen.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20202460

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Micrograph of the plasmodium falciparum virus

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.