Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.


Subscribe or Register

Existing user? Login

Drug combinations

Modelling approach could optimise drug combination choice

Researchers used polynomial modelling to simulate complex drug-dose effects and found that they could accurately predict the dose-effect function of drug combinations.

One challenge in predicting the efficacy of drug combinations is the vast number of potential multiples of drugs and dosages.

In a paper published in IEEE/CAA Journal of Automatica Sinica[1] (2017;4(1):41-48), researchers tested a method called polynomial modelling to simulate complex drug-dose effects.

By comparing different models, they found that they could accurately predict the dose-effect function of combinations involving more than six drugs.

The team showed that the model could be applied to exploring the optimal combination of eight chemotherapeutic drugs on three lung cancer cell lines, which they say could be used to target multiple tumour cell types in the same patient.

The team says the results could inform the use of algorithms to optimise virtually any kind of drug combination and to tailor treatment to individual patients.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20202255

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Chemotherapy drugs on tray

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.