Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Pain management

NSAIDs associated with significant improvement in chronic low back pain

Data from 13 clinical trials show efficacy of non-steroidal anti-inflammatory drugs in treating chronic low back pain.

Patients with chronic low back pain frequently use non-steroidal anti-inflammatory drugs (NSAIDs), but their overall efficacy remains unclear.

Researchers surveyed 13 trials, conducted between 1981 and 2011, to find out whether NSAIDs are associated with greater pain relief than placebo, other drugs and non-drug treatments for patients with chronic lower back pain.

Of the six studies that compared NSAIDs with placebo, NSAIDs were associated with a statistically significant improvement in pain intensity and disability. However, the magnitude of the association was small, and the evidence quality was low.

In one study comparing celecoxib with tramadol, celecoxib was associated with a better overall improvement in pain from baseline. In another study comparing NSAIDs to home-based exercise, disability improved more in patients who exercised but with no difference in pain scores.

Future research is needed to identify patients most likely to respond well to NSAIDs, the researchers conclude in the Journal of the American Medical Association[1] (13 June 2017).

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20203114

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Xray showing spine with lower back pain

Jobs you might like

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.