Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Antibiotics

Peptide inspired by Komodo dragon blood promotes wound healing

Researchers in the United States use peptide from Komodo dragon to enhance wound healing in mice.

Komodo dragon

Source: Shutterstock.com

Researchers have developed a synthetic peptide called DRGN-1 based on a histone H1-derived peptide from the Komodo dragon.

Wound infections are a major concern in medicine, further complicated by antibacterial resistance.

However, a cationic antimicrobial peptide found in the blood of the Komodo dragon may inspire a new treatment for promoting wound healing.

As part of a project funded by the US Defence Threat Reduction Agency, researchers have developed a synthetic peptide called DRGN-1 based on a histone H1-derived peptide from the Komodo dragon.

DRGN-1 was evaluated for its antimicrobial and antibiofilm activity against two stubborn biofilm-producing bacterial strains — Pseudomonas aeruginosa and Staphylococcus aureus.

DRGN-1 was found to make the bacterial membranes permeable and exhibit potential antimicrobial and antibiofilm activity as well as promote keratinocyte migration. Consequently, wound healing was significantly enhanced by DRGN-1 in both uninfected and mixed biofilm-infected wounds in mice.

Publishing their findings in NPJ Biofilms and Microbiomes[1] (online, 11 April 2017), the researchers conclude that DRGN-1 would make a good candidate for further development as a topical wound treatment.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20202630

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Komodo dragon

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.