Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Adverse drug reactions

PPI use not linked to osteoporotic fractures in Barrett’s oesophagus

Fractures are not uncommon in patients with the condition, but the rate is not higher than in the general population and is not associated with use of PPIs, researchers concluded.

Endoscopic view showing Barrett's oesophagus

Source: Gastrolab / Science Photo Library

Study finds that fractures are not uncommon in patients with Barrett’s oesophagus, but the rate is not elevated compared with the general population, nor increased by PPI use

Proton-pump inhibitors (PPIs) have been linked to osteoporotic fractures in some studies. However, there are limited data on this association among patients with Barrett’s oesophagus, who receive high doses of the drugs over long periods.

To explore, researchers carried out a study involving 521 patients with Barrett’s oesophagus to compare the rate of fractures with an age- and gender-matched population.

Overall, 21.7% of patients with Barrett’s oesophagus had fractures and 8.8% had osteoporotic fractures. These incidences were not significantly different from the general population (Standardised Incidence Ratio [SIR] 1.09; 95% CI 0.92-1.29: SIR 1.05; 95% CI 0.85-1.29). There was also no association between PPI use, dose or duration with osteoporotic fracture risk.

Reporting in Alimentary Pharmacology & Therapeutics (5 October 2017), the researchers said the results indicated that fractures are not uncommon in patients with Barrett’s oesophagus, but the rate is not elevated compared with the general population, nor increased by PPI use[1].

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20203969

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Endoscopic view showing Barrett's oesophagus

Jobs you might like

See more jobs

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.