Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Books

Applying pharmacokinetics to clinical practice

This well referenced text will show you how to apply pharmacokinetic principles to drug therapy in day-to-day practice.

Book cover of ’Clinical pharmacokinetics’

Clinical pharmacokinetics, 6th edition, edited by John E Murphy. Pp xxv+452. Price $99. Maryland: American Society of Health-System Pharmacists; 2017. ISBN 978 1 58528 236 5 eBook Price $89. eISBN 978 1 58528 537 2

This book was originally written to help practitioners predict drug doses to achieve target drug concentrations from doses administered to patients. Important chapters on rational use of drug concentration measurements, dosing in overweight and obese patients, dosing considerations for a wider variety of drugs used in neonatal, paediatric and geriatric patients, drug dosing in renal disease and creatinine clearance estimation have been added over the years. The book offers information for medicines that require an understanding of individual patients’ probable or actual drug concentrations to achieve medication effectiveness and safety.

In this expanded 6th edition, authors have taken advantage of advances in knowledge to update the chapters. In many cases, more judicious monitoring of drug concentrations is suggested compared with the earlier editions. In some cases, the dosing approaches are radically different and, in others, new prediction approaches are available that have been tested in larger numbers of patients. Many chapters have been updated to take into account emerging pharmacogenetics knowledge.

Pharmacogenomic issues are increasingly important in decisions about drug dosing or which patients should receive certain drugs. A new chapter has been added to help interpret issues related to applying pharmacogenomics to drug dosing.

General pharmacokinetic principles are discussed in the introductory chapter, including the reasons why some drug concentration measurements fall outside the expected range of population estimates. This chapter also includes a glossary of pharmacokinetic terms, selected pharmacokinetic symbols and a series of pharmacokinetic equations.

The main chapters are devoted to those drugs that require careful monitoring, such as aminoglycosides, antiepileptics, antidepressants, antirejection agents, carbamazepine, ethosuximide, digoxin, lithium, heparin, warfarin and several others.

Typically, each chapter includes the usual dose range, the bioavailability of the dose forms, general pharmacokinetic information (absorption, distribution, elimination, metabolism, protein binding), clearance, volume of distribution, half-life and time to steady state, therapeutic range, dosing strategies, sampling times, pharmacodynamic monitoring, drug-drug interactions, pharmacodynamic interactions, drug-disease interactions and references. A large number of references are cited at the end of each chapter.

Chapter authors represent a broad range of pharmacy practice, including those in clinical practice, academia and in medical departments of pharmaceutical companies.

This book shows practitioners and students how to apply pharmacokinetic principles to drug therapy in day-to-day practice. It is an excellent reference source, offering practitioners the key principles in pharmacokinetics and the application of these principles in drug therapy. Because the tables cover both international and traditional units for drugs and laboratory tests, the book can be used across the world. All who work in this area of practice should find this excellent book of great value.

Laurence A Goldberg

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2017.20203124

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Basic Pharmacokinetics

    Basic Pharmacokinetics

    A clear and concise basic pharmacokinetics textbook. Shows how to apply the principles to achieve successful drug therapy.

    £52.00Buy now
  • Clinical Pharmacokinetics

    Clinical Pharmacokinetics

    A practical guide to the use of pharmacokinetic principles in clinical practice. Includes case studies with questions and answers.

    £32.00Buy now
  • Financial Analysis in Pharmacy Practice

    Financial Analysis in Pharmacy Practice

    An introduction to the basics of accounting and financial management. Applies these principles to pharmacy practice.

    £37.00Buy now
  • Principles of Good Clinical Practice

    Principles of Good Clinical Practice

    A one-stop source for the proper conduct of clinical trials. Essential information on clinical trial design and pharmacovigilance.

    £48.00Buy now
  • Drugs in Use

    Drugs in Use

    Optimise drug therapy for your patients. These case studies help you bridge the gap between theoretical medicines knowledge and practical applications.

    £42.00Buy now
  • MCQs in Pharmacy Practice

    MCQs in Pharmacy Practice

    A study aid with 800 MCQs. Assess your knowledge, analytical skills, and ability to apply this knowledge base in clinical practice.

    £24.00Buy now

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • Book cover of ’Clinical pharmacokinetics’

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.