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Headline

The cholesterol and calorie hypotheses are both dead — it is time to focus on the real culprit: insulin resistance

Comment

Experiments in rats established many, many years ago that "the more you eat the sooner you die". In the human context, this should now be refined to read "the more [sugar] you eat the sooner you die". And since that first experiment in rats, billions have been spent on carrying out research into diseases that are ultimately caused by glucose (and indeed other reducing sugars) reacting with amino groups on amino acids (for which read "proteins") to form Schiffs bases that then, through a couple of further irreversible chemical steps (Maillard reaction), become "advanced glycation endproducts" (dubbed, for obvious reasons, AGEs). AGEs wreck proteins; those structural proteins that turn over most slowly in the body are the ones that take the biggest "hit". The chemical mechanisms by which this occurs are well described in the literature. The only way in which AGE production in the body can be slowed is by reducing dietary sugar intake and hence minimising the probability that the first Schiffs base reaction, which is reversible, does not progress to the downstream reactions leading to AGE formation. The medical professions seem unable to advise patients that notwithstanding the billions that have been spent on drug research into symptomatic treatments for the diseases ultimately caused by AGEs, and despite all the medication that we pharmacists dispense in good faith, the best "medicine" is simply to eat less ... in particular to eat / drink much less sugar (and to move about more).

Posted date

22 JUL 2017

Posted time

15:42

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