Scott M Grundy
Scott M Grundy is professor of internal medicine at the Center for Human Nutrition and Department of Internal Medicine, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Suite Y3.206 Dallas, TX 75390-9052, United States.
Primary prevention of cardiovascular disease with statins: assessing the evidence base behind clinical guidanceSubscription
Statins and other cholesterol-lowering drugs are increasingly being used for primary prevention of atherosclerotic cardiovascular disease. Three lines of evidence inform the development of therapeutic goals for both drug and lifestyle intervention. This evidence reveals the following principles for cholesterol lowering in primary prevention: (a) ‘the more (lowering), the better’ for relative risk reduction, (b) ‘the lower, the better’ for absolute risk reduction, and (c) ‘the earlier, the be