Category list : Anti-inflammatory agents
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Everything you need to know about the COVID-19 therapy trials
Researchers around the world are working at record speed to find the best ways to treat and prevent COVID-19, from investigating the possibility of repurposing existing drugs to searching for novel therapies against the virus.
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Anti-inflammatory drugs found to exert antidepressant effect Subscription
Anti-inflammatory agents exert an antidepressive effect in the treatment of major depressive disorder, a systematic review and meta-analysis published in the Journal of Neurology, Neurosurgery and Psychiatry has suggested.
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NICE recommends aspirin for cancer prevention for the first time Subscription
Aspirin has been recommended for cancer prevention in draft national clinical guidance for the first time.
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Prednisolone reduces hand osteoarthritis pain Subscription
Patients with hand osteoarthritis experienced improvements in pain and function with low-dose prednisolone treatment, according to a study presented at the European Congress of Rheumatology.
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Management of acute upper gastrointestinal bleeding Subscription
An overview of the assessment process for acute upper gastrointestinal bleeding in the hospital setting and the treatment options available.
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Study results do not support use of hydroxychloroquine in hand osteoarthritis Subscription
There is anecdotal evidence that the slow-acting anti-inflammatory treatment hydroxychloroquine, used to treat rheumatoid arthritis, could also be effective in osteoarthritis.
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A brief history of ibuprofen Subscription
This timeline traces the history of popular anti-inflammatory drug ibuprofen, from its invention in the 1960s to its association with cardiac side effects.
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High-dose vitamin D counteracts sunburn damage Subscription
A double-blinded, placebo-controlled interventional trial reveals high-dose vitamin D3 as a potent modulator of experimental sunburn induced by simulated solar radiation.
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Ustekinumab approved by NICE for treatment of Crohn’s disease
The National Institute of Health and Care Excellence (NICE) has approved ustekinumab (Stelara; Janssen) as a treatment for patients with moderate to severe Crohn’s disease who have had little or no response, or an intolerance, to existing therapies.
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Naturally-occurring peptide shows promise for CF treatment Subscription
Thymosin α1 is found to have strong potential to prevent the progression of cystic fibrosis.
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Combining NSAIDs with misoprostol may reduce risk of cardiovascular side effects
Patients taking non-steroidal anti-inflammatory drugs (NSAIDs) and misoprostol, a drug commonly used to prevent and treat stomach ulcers, have a lower risk of having a serious cardiovascular event compared with patients taking NSAIDs alone, according to new research.
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Management of patients with inflammatory bowel disease: current and future treatments Subscription
Inflammatory bowel disease (IBD) is characterised by chronic inflammation of the gastrointestinal tract and affects patients’ quality of life. Treatment of IBD involves induction and maintenance of remission. Current available therapies include anti-inflammatory aminosalicylates and corticosteroids, immunosuppressive agents, antibiotics and biologic agents. Some patients are not fully responsive to conventional treatment or lose efficacy over time. Recently approved ...
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Salicylic acid exposure might increase risk of Staphylococcus aureus Subscription
Animal research suggests that frequent consumption of aspirin could contribute to S. aureus infection.
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Diazepam should not be added to NSAIDs for acute lower back pain, researchers say
Study results show that 22% of patients taking placebo with naproxen for back pain reported moderate to severe pain, compared with 32% of patients taking diazepam with naproxen.
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Aspirin could help certain women get pregnant, study finds
Aspirin, an inexpensive and commonly available anti-inflammatory drug, could help some women who have had pregnancy losses in the past to sustain their pregnancy to a live birth, a new study suggests.
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TNFα-inhibitors for ankylosing spondylitis and non-radiographic axial spondyloarthritis Subscription
Spondyloarthropathy refers to a group of articular inflammatory diseases that share common genetic, clinical and radiological features in addition to their association with human leucocyte antigen (HLA)-B27 antigen. The aim of therapeutic management of patients with spondyloarthritis is to improve quality of life, control the symptoms of articular inflammation, prevent the structural damage of joints, and preserve the functional abilities, autonomy and social participation of patients. Althou
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Actavis accused of overcharging NHS for hydrocortisone tablets
The Competition and Markets Authority (CMA) has accused pharmaceutical company Actavis UK of breaking competition law by charging the NHS excessive prices for hydrocortisone tablets.
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DMARDs do not increase post-surgical infection risk Subscription
Rates of post-surgical infections did not increase for patients taking disease-modifying anti-rheumatic drugs and biologics, researchers discover.
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Methylprednisolone as effective as gentamicin for Ménière’s disease Subscription
Study shows that methylprednisolone and gentamicin are equally as effective in controlling vertigo attacks.
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Anti-inflammatory drugs could treat symptoms of depression
Anti-cytokine drugs typically prescribed to treat inflammatory conditions, such as rheumatoid arthritis and psoriasis, can also improve symptoms of depression, according to new research.
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Risk associated with NSAID use is very small for people aged under 65 years Subscription
29 September 2016: A study published in The BMJ looked at 10 million people and found that taking nonsteroidal anti-inflammatory drugs (NSAIDs) increased the risk of being taken to hospital with heart failure. Helen Williams, a consultant pharmacist in cardiovascular medicine, appeared on Radio 4’s Today Programme, BBC TV’s Victoria Derbyshire programme and the BBC One O’Clock News and said: “For most people, the risk of using an NSAID like ibuprofen is very small. ...
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Anti-inflammatory drugs linked with higher risk of heart failure
High doses of some non-steroidal anti-inflammatory drugs can double the risk of being admitted to hospital for heart failure.
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Intranasal steroids underused in chronic sinusitis
Topical intranasal steroids are underused among patients with chronic rhinosinusitis, a Canadian study has revealed.
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Alzheimer’s inflammation targeted with period pain NSAID Subscription
Flufenamic acid and mefenamic acid successfully reduced inflammation and memory deficits in rodent model of Alzheimer’s disease.
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Widely used NSAID treats Alzheimer’s disease in mice
The anti-inflammatory drug mefenamic acid can reverse memory loss and brain inflammation in a mouse model of Alzheimer’s disease, a study shows.
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Early treatment may benefit patients with MS
Researchers have discovered that starting treatment for multiple sclerosis when patients first show possible symptoms may prolong the time before the disease is clinically diagnosed.
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Advising patients on prevention and management of sporting injuries in the pharmacy Subscription
How to identify common sporting injuries and provide specific advice to patients on their effective management, including the role of over-the-counter pharmacological treatments, as well as when to refer for specialist assessment and treatment.
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Paracetamol ineffective in treating osteoarthritis, meta-analysis finds Subscription
Paracetamol is not clinically effective for alleviating pain and improving physical function in patients with osteoarthritis, the largest analysis of randomised trials of analgesics for osteoarthritis published to date has found.
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The man who discovered ibuprofen Subscription
Ibuprofen is one of the world’s best selling anti-inflammatory painkillers. Its pioneer, Stewart Adams, now 92 years old, tells Julia Robinson about how and why his discovery came to fruition.
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NICE recommends drugs for ankylosing spondilitis Subscription
The National Institute for Health and Care Excellence (NICE) has issued guidance recommending adalimumab, certolizumab pegol, etanercept, golimumab and infliximab, within their marketing authorisations, as options for treating severe active ankylosing spondylitis in adults whose disease has responded inadequately to, or who cannot tolerate, non‑steroidal anti‑inflammatory drugs. Full details of the recommendations can be found on the
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Top 10 news stories for 2015
Drug safety was a hot topic in 2015, accounting for five of the top 10 news stories consumed by our readers.
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Schizophrenia: investigating the role of the immune system Subscription
Research on psychosis is leading to treatments tailored to the individual’s underlying disease process, with particular attention turning to the role of the immune system.
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Ibuprofen could provide alternative to antibiotics for uncomplicated UTIs
Two-thirds of women found ibuprofen to be sufficient treatment for uncomplicated infection.
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Review of 2015: ten developments that are changing pharmacy Subscription
The pharmacy landscape continues to shift amid a backdrop of austere UK public spending and the rising spectre of centralised dispensing in the community. The Pharmaceutical Journal presents ten developments that affected pharmacists in 2015.
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Spinal surgery: an overview Subscription
Understanding the rationale for surgery and appropriate pharmaceutical care.
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Case study: management and counselling of a patient with rheumatoid arthritis Subscription
Exploring questions to be considered when managing a patient with rheumatoid arthritis.
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Combining naproxen with other analgesics does not improve low back pain Subscription
A ten-day course of naproxen and placebo was just as effective at relieving low back pain as naproxen combined with other pain medications.
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Dry eye disease: risk factors and selecting treatment Subscription
Identifying the risk factors for dry eye disease and selecting the most appropriate and effective treatments.
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Dexamethasone improves septic arthritis in children Subscription
Taking dexamethasone with antibiotic treatment was found to enhance recovery in children diagnosed with septic arthritis.
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Small molecule halts preterm birth in mice Subscription
Inflammation is associated with preterm birth, so researchers developed a small molecule that inhibits the proinflammatory cytokine interleukin 1 which is effective in a mouse model.
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First-in-class drug for sepsis and acute respiratory distress syndrome on the horizon Subscription
Researchers at Queen’s University in Belfast are developing a new anti-inflammatory drug that could help treat sepsis and acute respiratory syndrome
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Oral contraceptives may improve inflammatory arthritis outcomes Subscription
Taking oral contraceptives may benefit women who have inflammatory arthritis, according to research published in Arthritis Care and Research.
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Scientists develop hydrogel to directly target disease sites in inflammatory bowel disease Subscription
Researchers have developed a hydrogel that selectively delivers drugs to inflamed tissue, which could pave the way for improved treatment options for patients with inflammatory bowel disease, according to a study published in Science Translational Medicine.
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Corticosteroids may reduce mortality in community-acquired pneumonia Subscription
Corticosteroids significantly reduce mortality, the need for mechanical ventilation and hospital stay in adults with community acquired pneumonia, say researchers.
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Humira indicated for Hidradenitis suppurativa Subscription
Humira (adalimumab; AbbVie) is now indicated for the treatment of Hidradenitis suppurativa — an inflammatory skin condition that causes painful abscesses and scarring around the armpits, groin, buttocks and breasts. The medicine is the first to be licensed for the condition. Humira is also used for a number of other inflammatory conditions, such as rheumatoid arthritis.
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Scotland brings in medicine card to avoid kidney injury after dehydration Subscription
Pocket-sized patient information cards that warn patients to temporarily stop taking specific medicines if they have a dehydrating illness are being introduced across Scotland.
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Trauma to joints can increase risk of psoriatic arthritis Subscription
Patients with psoriasis who experience trauma to the joints or bones are up to 50% more likely to go on to develop psoriatic arthritis, finds new research.
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Biological agents can reduce work absenteeism in patients with rheumatic disease Subscription
Patients with rheumatic disease who are treated with biological drugs miss fewer days of work and are more productive than patients treated with non-biological agents, reveals a meta-analysis.
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Rheumatoid arthritis patients should be offered intensive treatment when first diagnosed Subscription
Evidence to support intensive treatment with disease-modifying anti-rheumatic drugs when patients are first diagnosed with rheumatoid arthritis has been presented at the Annual European Congress of Rheumatology.
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