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Category list : Combination products

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  • Polypill

    Power of one: what is holding polypills back? Subscription

    20 SEP 2019 12:41 By Harriet Pike

    Single pills with fixed-dose combinations of several medicines are not commonplace for the treatment of cardiovascular disease. As the first randomised controlled trial to show a polypill can cut the risk of heart attacks is published, we look at why, nearly two decades after it was first proposed, development and uptake is limited. 

  • combined sofosbuvir treatment for hepatitis C

    Combination treatment for hepatitis C approved by FDA

    20 JUL 2017 11:14

    The US Food and Drug Administration (FDA) has approved the use of the combination treatment Vosevi (sofosbuvir, velpatasvir and voxilaprevir) for the treatment of adults with chronic hepatitis C virus (HCV) genotypes 1–6 without cirrhosis or with mild cirrhosis.

  • Chemotherapy drugs on tray

    Modelling approach could optimise drug combination choice Subscription

    7 FEB 2017 10:00

    Researchers used polynomial modelling to simulate complex drug-dose effects and found that they could accurately predict the dose-effect function of drug combinations.

  • Chest x-ray showing COPD

    COPD patients who use opioids at risk from respiratory complications

    19 JUL 2016 16:49 By Debbie Andalo

    Older patients with chronic obstructive pulmonary disease who take opioids to relieve their symptoms increase their risk of dying from a respiratory-related complication compared with non-opioid users, according to new research.

  • Malignant melanoma

    Combination immunotherapy for advanced melanoma gets early approval from NICE

    17 JUN 2016 16:05

    The immunotherapy combination nivolumab/ipilimumab has been recommended for patients with advanced malignant melanoma, according to draft guidance from the National Institute for Health and Care Excellence (NICE). 

  • Micrograph of human immunodeficiency virus (HIV) virions

    High-risk women need more frequent doses of HIV drugs Subscription

    8 MAR 2016 16:31

    Researchers say more frequent pre-exposure prophylaxis is required to protect women from HIV.

  • MRI scan of breast cancer

    Palbociclib drug combination slows advanced breast cancer Subscription

    7 MAR 2016 14:20 By Ingrid Torjesen

    Combining the first-in-class targeted drug palbociclib with the hormone drug fulvestrant delays the progression of advanced breast cancer by an average of nine months — twice as long as when fulvestrant was given alone — a study shows.

  • Cyramza indication extended Subscription

    12 FEB 2016 12:37

    The indication of Cyramza (ramucirumab; Eli Lilly), in combination with FOLFIRI (irinotecan, folinic acid, and 5‑fluorouracil), has been extended to include the treatment of adult patients with metastatic colorectal cancer with disease progression on or after prior therapy with bevacizumab, oxaliplatin and a fluoropyrimidine. In addition, Cyramza in combination with docetaxel is also indicated for the treatment of adult patients with locally advanced or metastatic non-small cell lung ...

  • International study finds high proportion of HIV patients were resistant to cART drug tenofovir. In the image, micrograph of HIV budding from a lymphocyte

    HIV resistance to tenofovir surprisingly common Subscription

    11 FEB 2016 9:56

    International study finds high proportion of HIV patients were resistant to cART drug tenofovir.

  • Research found that pre-exposure prophylaxis, taken at the time of sexual activity, reduced the risk of HIV transmission by 86% compared with placebo among men who have sex with men. In the image, close up of Truveda pill used for pre-exposure prophylaxis

    On-demand prophylaxis protects against HIV infection in at-risk men Subscription

    9 DEC 2015 11:12

    Randomised trial shows pre-exposure prophylaxis reduced the risk of HIV transmission by 86%.

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