Issue : Clinical Pharmacist, April 2016, Vol 8, No 4
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Bipolar disorder: pharmacotherapy options with a focus on women of childbearing age Subscription
Bipolar disorder and its implications for women of childbearing age, with a focus on the use of valproate and how this compares to other available pharmacologic treatments.
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Bridging anticoagulation: perioperative management of patients on anticoagulants Subscription
How patients on anticoagulants can be effectively managed in the perioperative period, including the evidence for the need for ‘bridging’ anticoagulation therapy and introduction of direct oral anticoagulants.
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Enthusiasm for PCSK9 inhibitors to lower LDL cholesterol is premature Subscription
Although PCSK9 inhibitors have been hailed as the next big thing in the treatment of high cholesterol, there are not enough data to make informed opinions about their overall value.
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E-cigarettes in smoking cessation: a harm reduction perspective Subscription
Electronic cigarettes (e-cigarettes) are novel devices that simulate aspects of cigarette smoking and deliver nicotine to users. Evidence for their efficacy in smoking cessation, based on several randomised controlled trials of older devices, suggests a modest effect. They appear to be far less harmful than tobacco smoking, but the health effects of long-term use are unknown. Possible adverse population effects of widespread e-cigarette use, such as renormalising smoking ...
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The effectiveness of granisetron transdermal patch in chemotherapy-induced nausea and vomiting Subscription
Chemotherapy-induced nausea and vomiting (CINV) is one of the most distressing side effects of chemotherapy. It can have a negative impact on quality of life and may discourage patients from continuing treatment. Economic impacts include costs of prolonged hospital stays, emergency admissions for dehydration, additional treatments, emotional support and depression. In severe cases, CINV could lead to serious complications and clinical decisions may be made to delay, reduce or stop chemotherapy.
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Antidepressant class not linked to increased cardiovascular risk Subscription
Study of nearly 240,000 patients shows SSRI antidepressants are not linked with increased risk of cardiovascular events.
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Curcumin boosts immune cell power against tuberculosis Subscription
Incubating cells with turmeric compound reduced Mycobacterium tuberculosis infection.
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Follow-up more than six weeks after heart attack linked to reduced medication adherence Subscription
Researchers looked at the effect of follow-up appointments on medicine adherence following acute myocardial infarction.
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Omalizumab reduces colds in children with asthma Subscription
Children treated with omalizumab had 27% fewer colds then those treated with guideline-based care.
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Community pharmacies effective at public health interventions Subscription
A systematic review of public health interventions in community pharmacies showed they were as effective as usual care.
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Medication burden has major role in patient experiences Subscription
Analysis of 1,144 patients finds intolerable medication burden may result in non-adherence and poor outcomes.
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ACE inhibitors and ARBs equally effective in diabetics Subscription
Researchers find ACE inhibitors and ARBs produce similar outcomes in analysis of more than 100,000 diabetic patients.
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Meldonium use widespread among elite athletes Subscription
Research finds 43 of the 66 athletes who tested positive for meldonium during 2015 European Games in Azerbaijan did not declare it.
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Existing drugs could fight lethal viral infections Subscription
Researchers say repurposed drugs, such as bupicavaine, haloperidol and fluoxetine, could treat bunyavirus infection
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Degludec liraglutide combination improves glucose control in type 2 diabetes Subscription
Combination of insulin and GLP-1 receptor agonists could help control glucose in type 2 diabetes, researchers suggest.
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High-risk women need more frequent doses of HIV drugs Subscription
Researchers say more frequent pre-exposure prophylaxis is required to protect women from HIV.
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Improving the use of medicines in East Cheshire Subscription
East Cheshire’s Neighbourhood Integrated Medicines Optimisation (NIMO) team started as a small pharmacy project three years ago but, following clinical commissioning group financial support, a pharmacy service was developed and carved into this rural region.
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Bisphosphonate prevents bone loss during HIV treatment Subscription
A dose of zoledronic acid at the same time as antiretroviral therapy reduces bone resorption, a phase II clinical trial suggests.
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Foods that cause blood glucose spike Subscription
On the subject of obesity, there is some interesting work appearing. It relates to the body’s blood sugar response to various foods and also to the composition of one’s gut bacterial flora. For me, the blood glucose spike is the most interesting bit. What is clear is that blood glucose spikes that occur eating or drinking are a bad thing.
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