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Issue : PJ November 2015 online

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  • Patients with subarachnoid haemorrhage (SAH) developing stress-induced cardiomyopathy (SIC), coloured x-ray pictured. Research found that these patients had higher peak levels of the cardiac damage peptides hsTnT and NTproBNP

    Two peptides predict cardiomyopathy after brain haemorrhage Subscription

    3 DEC 2015 11:06

    Swedish PhD student finds biomarkers that can identify subarachnoid haemorrhage patients at risk of cardiomyopathy.

  • Research shows a blood test could predict which antidepressant will work for each patient. In the image, blood from tests ready to be analysed

    Blood test could show whether an antidepressant is effective, research suggests Subscription

    2 DEC 2015 9:52 By Bea Perks

    Psychiatrists could be on the way to developing a test that predicts which patients with depression will benefit from which antidepressant.

  • Necitumumab (Eli Lilly’s Portrazza) has been approved by the US drugs safety watchdog for patients with advanced squamous non-small cell lung cancer (NSCLC), image attached, who have not received other treatment for their advanced disease

    FDA approves necitumumab for non-small cell lung cancer Subscription

    1 DEC 2015 15:19

    Necitumumab (Portrazza) has been approved by the US drugs safety watchdog as a new combination therapy for patients with advanced squamous non-small cell lung cancer who have not received other treatment for their advanced disease.

  • Researchers have found that the glucagon-like peptide-1 analogue liraglutide – a treatment for type 2 diabetes – is also effective in non-alcoholic steatohepatitis (NASH), micrograph pictured

    Diabetes treatment effective in liver disease Subscription

    30 NOV 2015 16:41

    Almost two fifths of patients given liraglutide had resolution of the common liver disease called NASH.

  • Pharmacist Rob Morris (pictured) has spent his career developing and selling medicines for farm animals and pets. He encourages other pharmacists to consider the sector, even though jobs may be scarce.

    Why I chose veterinary pharmacy instead of community or hospital Subscription

    30 NOV 2015 16:16 By Rob Morris

    Practising veterinary pharmacy offers flexibility and creativity that the traditional sectors do not, writes Rob Morris.

  • NICE does not recommend apremilast Subscription

    30 NOV 2015 15:44

    The National Institute for Health and Care Excellence (NICE) does not recommend apremilast (Otezla; Celgene) for treating some adults with moderate to severe chronic plaque psoriasis.  

  • NICE recommends pembrolizumab Subscription

    30 NOV 2015 15:42

    The National Institute for Health and Care Excellence (NICE) recommends pembrolizumab (Keytruda; Merck, Sharp & Dohme) as a treatment option in adults with advanced melanoma that has not been previously treated with ipilimumab when the company provides pembrolizumab with the discount agreed in the patient access scheme.

  • New NICE recommendations for hepatitis C Subscription

    30 NOV 2015 13:52

    The National Institute for Health and Care Excellence has published final guidance recommending ledipasvir-sofosbuvir (Harvoni; Gilead Sciences), ombitasvir-paritaprevir-ritonavir with or without dasabuvir (Viekirax ...

  • NICE recommends vortioxetine Subscription

    30 NOV 2015 13:47

    The National Institute for Health and Care Excellence (NICE) has published final guidance that recommends vortioxetine (Brintellix; Lundbeck, Takeda) as third-line treatment for major depressive episodes. Vortioxetine should be considered as a treatment option for adults whose condition has responded inadequately to two antidepressants within the current episode.

  • Caution with concomitant Zelboraf and radiation treatment Subscription

    30 NOV 2015 13:42

    The summary of product characteristics for Zelboraf (vemurafenib; Roche) now states that cases of radiation recall and radiation sensitisation have been reported in patients treated with radiation either prior, during, or subsequent to vemurafenib treatment. Therefore, vemurafenib should be used with caution when given concomitantly or sequentially with radiation treatment.

  • Fostair NEXhaler indicated for COPD Subscription

    30 NOV 2015 13:33

    Fostair NEXhaler (beclometasone diproprionate, formoterol fumarate dihydrate; Chiesi) is now indicated for patients with chronic obstructive pulmonary disease. Further changes to the summary of product characteristics reflect this addition.

  • Draft guidance for recurrent ovarian cancer Subscription

    30 NOV 2015 13:24

    The National Institute for Health and Care Excellence (NICE) has published draft guidance that covers five drugs — paclitaxel, pegylated liposomal doxorubicin hydrochloride (PLDH), topotecan, trabectedin and gemcitabine — for treating recurrent ovarian cancer. The guidance recommends paclitaxel and PLDH for treating recurrent ovarian cancer but proposes not recommending gemcitabine, topotecan and trabectedin for treating the first recurrence of platinum-sensitive ovarian cancer (where ...

  • Edurant indication extension for adolescents Subscription

    30 NOV 2015 13:14

    The summary of product characteristics for Edurant (rilpivirine; Janssen-Cilag) now states that the drug can be taken by adolescents of 12 years and above, as well as adults. 

  • Hospital stock control of antidotes to treat poisoned patients have improved but there is still “significant” differences between NHS trusts, according to research published. In the image, stock of medicines in a hospital pharmacy

    Hospitals have variable stock levels of antidotes Subscription

    27 NOV 2015 16:58
    Comments (1)

    Hospital stock control of antidotes to treat poisoned patients have improved but there is still “significant” differences between NHS trusts.

  • Intestinal obstruction with Xifaxanta Subscription

    27 NOV 2015 15:08

    Intestinal obstruction is now listed as an adverse reaction in the summary of product characteristics for Xifaxanta (rifaximin; Norgine). Additionally, the drug may reduce the effectiveness of oral estrogenic contraceptives if taken concomitantly. Caution should also be exercised when rifaximin is given concomitantly with a P-glycoprotein inhibitor, such as ciclosporin.

  • Contraindications with Aldomet Subscription

    27 NOV 2015 14:53

    Aldomet (methyldopa; Aspen) is now contraindicated with a catecholamine-secreting tumour, such as pheochromocytoma or paraganglioma, and with porphyria. Additionally, the summary of product characteristics now states that the use of the drug in women who are pregnant or may become pregnant, or in breast-feeding mothers, requires that the anticipated benefits are weighed against potential risks.

  • Cormac Tobin (pictured), managing director of Celesio UK, which owns John Bell & Croyden, describes the history of the pharmacy and explains what changes have been made

    How we refurbished a famous London pharmacy Subscription

    27 NOV 2015 14:43 By Cormac Tobin

    John Bell & Croyden pharmacy, which first opened over 200 years ago and holds the Royal warrant, has just had a £4m makeover.

  • Side effects with Eviplera Subscription

    27 NOV 2015 14:30

    The summary of product characteristics for Eviplera (emtricitabine, rilpivirine, tenofovir disoproxil; Gilead) now states that Eviplera must be discontinued as soon as serious skin and/or mucosal reactions are observed, and appropriate therapy should be initiated. 

  • Researchers report that disulfiram, molecular structure pictured), a drug used to treat alcoholism, can reactivate latent HIV. The findings represent a step towards eliminating latent HIV

    Alcoholism drug could help eliminate dormant HIV Subscription

    27 NOV 2015 14:28

    Disulfiram treatment can reactivate latent HIV, which could help eliminate the cells harbouring the virus, report finds.

  • Contraindication for Diflucan Subscription

    27 NOV 2015 14:22

    Concomitant administration of amiodarone is now contraindicated with Diflucan (fluconazole; Pfizer), according to the updated summary of product characteristics.

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