Category list : Anti-obesity agents
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Orlistat side effects were underreported, study shows
Adverse effects that occurred during clinical trials of Roche’s obesity drug orlistat in the 1990s appear to have been substantially underreported in both published papers and summarised clinical study reports submitted to the European Medicines Agency for drug approval, an analysis has found.
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Bitter plant extract suppresses appetite Subscription
A non-nutritive plant-based ingredient called Amarasate extract is effective in suppressing appetite, study finds.
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Obesity drugs show weight loss effect after one year
Five drugs approved in the United States for the treatment of obese or overweight adults have been associated with at least a 5% drop in weight after a year, a meta-analysis has shown.
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Cardiovascular safety of naltrexone-bupropion combination remains uncertain after termination of trial Subscription
Researchers have highlighted the importance of data confidentiality during clinical trials after they were forced to abandon their study when interim findings were made public.
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Review of 2015: ten developments that are changing pharmacy Subscription
The pharmacy landscape continues to shift amid a backdrop of austere UK public spending and the rising spectre of centralised dispensing in the community. The Pharmaceutical Journal presents ten developments that affected pharmacists in 2015.
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Second clinical trial death puts the future of obesity drug in doubt Subscription
The US Food and Drug Administration has given the pharmaceutical company Zafgen a verbal notice that its investigational new drug application for beloranib has been put on complete clinical hold after the death of a patient during a phase III clinical trial.
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Liraglutide has positive effects on bone metabolism in obese women Subscription
Data on liraglutide’s effects on bone metabolism support its use as an anti-obesity therapy, say researchers.
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Obesity: current and emerging drug treatments Subscription
The prevalence of obesity has doubled worldwide since 1980, but a range of new treatments are being introduced to help patients lose weight.
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Weight loss drugs: the wrong answer to the obesity problem Subscription
Weight loss drugs are not the solution to achieve sustainable weight loss and improve overall health.
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Antioxidant prevents weight gain but effect in mice only seen in females Subscription
A naturally occurring antioxidant — 7,8-dihydroxyflavone (7,8-DHF) — mimics brain-derived neurotrophic factor (BDNF), a hormone secreted after physical exercise that controls weight gain.
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Clinical Pharmacist's monthly news round-up: the top 10 in the past month Subscription
What has been happening in the world of pharmacy? Here’s our pick of must-read news from the past month.
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EMA recommends approval of liraglutide as weight loss drug Subscription
The European Medicines Agency is recommending that the prescription-only injectable drug liraglutide (Saxenda) should be granted a marketing authorisation as a weight loss product.
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Can a lemon ever taste sweet?
Pam Mason explains why the flavour of what you have just eaten can change the flavour of what you eat next.
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Is bariatric surgery the right approach to obesity? Subscription
Up to a million more people could be offered weight loss surgery on the NHS after NICE lowered the threshold for which patients are eligible for bariatric surgery. David Haslam, GP and chairman of the National Obesity Forum UK, and David Katz, director, Yale University Prevention Research Center, discuss the merits of the decision, and the use of ...
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Drug for ADHD shows promise for treating binge eating disorder Subscription
A drug approved for the treatment of attention deficit-hyperactivity disorder, lisdexamfetamine dimesylate, cuts the number of binge eating days in people with binge eating disorder, according to a study.
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Making foods more filling could help tackle obesity
Adding a chemical that helps to cause satedness after eating to food may help to reduce the amount that individuals eat and therefore reduce weight gain.
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Scientists develop drug that curbs weight gain without reducing food intake Subscription
Scientists have developed a drug that curbs weight gain and corrects the metabolic defects associated with obesity without reducing food intake.
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Injectable weight loss drug liraglutide approved by FDA Subscription
The US Food and Drug Administration has approved liraglutide, an injectable drug best known as an antidiabetes agent, to treat obesity in combination with lifestyle changes such as a reduced-calorie diet and exercise.
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Researchers pinpoint new approach to treating obesity Subscription
Researchers have identified group 2 innate lymphoid cells for the first time in human white adipose tissue and shown that it limits obesity.
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FDA adds another weight loss drug to the US market Subscription
Combination therapy Contrave is the third weight loss drug to be approved by the US FDA in recent years.
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Weight loss drug orlistat may reduce the absorption of HIV medicines
Orlistat, a weight loss drug, may theoretically reduce the absorption of antiretroviral HIV medicines, says the Medicines and Healthcare products Regulatory Agency in its latest Drug Safety Update (March 2014). It recommends that orlistat should only be started after careful consideration of the possible impact and that people on antiretrovirals should consult their doctor before ...
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Government urged to target anti-obesity campaigns at women
Leading clinicians are urging the Government to fund campaigns demonstrating that obesity problems begin before conception and put both mother and child at risk from serious diseases.
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Anti-obesity drugs needed unless attitudes change
Unless there is a complete revision of attitudes to obesity, drug therapies should continue to play an important role in treatment, the authors of a Lancet article published online on 27 October argue.
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Anti-obesity drug does not produce meaningful weight loss
An experimental weight loss drug known as MK-0557 is unlikely to be sufficient as monotherapy to treat obesity, the results from a recently published trial suggest (Cell Metabolism 2006;4:275).
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PJ Online | News | Anti-obesity drug also helps smokers avoid weight gain
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PJ Online | News: Guidance on anti-obesity drugs
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PJ Online | News: Report highlights monitoring requirement for anti-obesity drugs
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PJ Online | News: Novel strategy for anti-obesity drugs
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PJ Online | News: Anti-obesity drug criticised by the DTB but supported by NICE advice
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