Category list : Antiviral agents
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Pre-exposure prophylaxis necessary to reduce HIV infection rate among MSM Subscription
Offering men who have sex with men antiretroviral therapy as pre-exposure prophylaxis is necessary if the UK is to achieve a marked reduction in the annual rate of HIV infections by the end of this decade, according to new research.
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Antiviral prescribing for influenza Subscription
The Department of Health (DH) has said that antiviral medications may now be prescribed at NHS expense for prophylaxis and treatment of influenza. This follows a recent increase in influenza virus activity. Antivirals should be considered for patients at risk of severe complications from influenza, or if they are in a “clinical at risk group”. More information can be found
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Fuzeon product update Subscription
The summary of product characteristics of the HIV medication Fuzeon (enfuvirtide; Roche) powder for solution for injection has been updated to warn that as a peptide, enfuvirtide can cause cutaneous amyloidosis at the injection site.
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On-demand prophylaxis protects against HIV infection in at-risk men Subscription
Randomised trial shows pre-exposure prophylaxis reduced the risk of HIV transmission by 86%.
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Alcoholism drug could help eliminate dormant HIV Subscription
Disulfiram treatment can reactivate latent HIV, which could help eliminate the cells harbouring the virus, report finds.
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People taking HIV drugs rises to almost 16 million, UNAIDs reports Subscription
The number of people receiving HIV treatment reached 15.8 million in June 2015, an increase of 2.2 million on the previous year, says a new report by UNAIDS.
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Errors in the BNF for Children Subscription
An error has been found in the new British National Formulary (BNF) for Children (2015–2016) regarding the indications of aciclovir. Some indications are omitted or are unclear.
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Reyataz boosted regimen Subscription
Ordinarily, treatment of HIV-1 with Reyataz (atazanavir; Bristol Myers Squibb) is boosted by co-administration with ritonavir. However, the summary of product characteristics has been updated to reflect that, under certain circumstances, ritonavir does not need to be co-administered, for example in patients with hepatic impairment.
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Sustiva oral solution discontinued Subscription
Sustiva oral solution 30mg/ml (efavirenz), used to treat HIV infection, has been discontinued by Bristol Myers Squibb. The “capsule sprinkle” method has been upgraded to the primary dosing method for patients who cannot swallow pills. In addition, as a result of the Sustiva oral solution discontinuation, the paediatric indication for the Sustiva hard capsules and film coated tablets has been extended to include children from three months of age and weighing at least 3.5kg.
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Tamiflu and Relenza need a better evidence base for influenza, report finds Subscription
The evidence base for influenza drugs such as oseltamivir (Tamiflu) and zanamivir (Relenza) must be strengthened, says a report from the Wellcome Trust and the Academy of Medical Sciences.
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