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Antimicrobial stewardship

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  • Micrograph of Clostridium difficile bacteria

    Clostridium difficile: diagnosis and treatment update Subscription

    There are around 12,000 cases of Clostridium difficile infection (CDI) each year in the UK and during 1999 to 2007, deaths from CDI peaked at around 4,000 per year. This article summarises diagnosis and management, as well as the current therapeutic options for CDI, including faecal microbiota transplant.

  • 2017 end of year review concept

    2017: Pharmacy's roller-coaster year Subscription

    It has been an unsettling 12 months for pharmacy and as 2017 draws to a close there are still a number of unresolved issues hanging over the New Year.

  • Research on antimicrobial resistance

    AMR and diagnostics: pointing the way to better infection control Subscription

    Antimicrobial resistance — the ability of previously sensitive microorganisms to resist the effects of an antimicrobial agent — is a growing problem. The World Health Organization has warned that we could be moving into a post-antibiotic era where even minor injuries could lead to life-threatening infections, consequently putting an end to complex surgery and returning us to an era where childbirth is high-risk.

  • Mycoplasma genitalium bacteria

    Antibiotic treatment of Mycoplasma genitalium infection Subscription

    An overview of the 2018 guideline for management of this sexually transmitted infection in men and women.

  • Antimicrobial management - mechanisms of acquired resistance Subscription

    The use of antibiotics for treating bacterial infections is based on the fact that they exhibit selective toxicity. That is to say, they inhibit or kill bacteria but usually have minimal or no adverse effects on the cells or tissues of the infected host.

  • Antimicrobial management - the role of clinical pharmacists Subscription

    Micro-organisms resistant to antimicrobials, especially those with multiple resistances, are causing concerns within health care systems throughout the world. Infections become more difficult to treat and patients stay longer in hospital, with the associated increases in costs. Furthermore, because less safe antimicrobial agents have to be used when the more safe alternatives are no longer suitable due to resistance, the prevalence of unwanted effects of the medicines tends to increase

  • Scanning electron micrograph of methicillin-resistant Staphylococcus aureus (MRSA) bacteria

    Antimicrobial therapies for Gram-positive infections Subscription

    Gram-positive bacteria are among the most common human pathogens associated with clinical infections, which range from mild skin infections to sepsis. In an era defined by antimicrobial resistance (AMR) and an increasing drive toward delivering patient care via ambulatory pathways, the paradigm for the management of infections is changing. Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE), the best known cases of ...

  • Micrograph of Acinetobacter baumannii bacteria

    Ceftazidime-avibactam: a novel cephalosporin/β-lactamase inhibitor Subscription

    Over the past decade, infections caused by multidrug-resistant Gram-negative organisms have increased. The limited availability in treatment options for these infections prompted both the UK to create a five-year antimicrobial resistance strategic plan to stimulate the development of new antibiotics, and the Infectious Diseases Society of America to call for ten new antimicrobial agents to be developed by 2020. Ceftazidime-avibactam is a combination of a third-generation ...

  • Current treatments for resistant infections Subscription

    Enterobacteriaceae are a family of Gram negative rods, the medically important members of which can be found in the lower gastrointestinal tract of humans and animals as well as in soil and water (see Panel 1). These organisms can be involved ...

  • Delayed antibiotics does not reduce long-term reconsultation (POEM) Subscription

    Clinical question: Does delayed antibiotic prescribing for acute respiratory infections reduce the rate of consultation for subsequent respiratory infections?

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