Infectious diseases - the need for new antibiotics Subscription
What went wrong with antibiotics, was a question posed in a leading article in the BMJ. It offered suggestions on ways to promote the rational use of antibiotics in order to stem the development of microbial resistance and to save money.This article appeared in 1984.1
The use of antibiotics for treating bacterial infections is based on the fact that they exhibit selective toxicity. That is to say, they inhibit or kill bacteria but usually have minimal or no adverse effects on the cells or tissues of the infected host.
Micro-organisms resistant to antimicrobials, especially those with multiple resistances, are causing concerns within health care systems throughout the world. Infections become more difficult to treat and patients stay longer in hospital, with the associated increases in costs. Furthermore, because less safe antimicrobial agents have to be used when the more safe alternatives are no longer suitable due to resistance, the prevalence of unwanted effects of the medicines tends to increase
Time to review short courses of antibiotics Subscription
Edward C. F. Wilson, MSc, is lecturer in health economics, Health Economics Group, School of Medicine, Health Policy and Practice, University of East Anglia, Norwich.John V. Wilson, MRPharmS, FRSPH, is pharmacist (retired) and former regional prescribing adviser, NHS Executive, Trent.
Peri-operative antibacterial prophylaxis Subscription
When is peri-operative antibacterial prophylaxis appropriate?