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Coeliac disease pathology and drug targets

In coeliac disease, the indigestible part of gluten gets through a leaky intestinal wall to come into contact with immune cells, stimulating a response in T cells, leading to the production of antibodies, a killer T-cell attack on gut epithelial cells, and the secretion of inflammatory molecules. Some potential coeliac disease treatments work by hiding any accidentally ingested gluten from the immune system while others attempt to dampen the immune response to gluten.

Source  Alessio Fasano and Joseph Murray