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The Medicines and Healthcare products Regulatory Agency (MHRA), which regulates drugs and devices in the UK, has updated its advice concerning the increased risk of lower limb amputation associated with canaglifozin, a drug used to treat type 2 diabetes.

The MHRA and EMA used data from two ongoing clinical trials to inform their updates, the results of which show that canagliflozin potentially increases the risk of lower limb amputation

Source  BSIP SA / Alamy Stock Photo