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Figure: Percentage of gonococcal isolates resistant to selected antimicrobials

The use of benzathine and procaine penicillin between the 1940s and 1970s led to a high level of penicillin resistance by the 1980s; Tetracycline resistance in the UK was reported in 37% of cases by the 2000s; Ciprofloxacin resistance was described at 22% in 2005; Azithromycin resistance was observed in 9.8% of isolates sent to Public Health England in 2018. Key: 1 = minimum inhibitory concentration (MIC) 2 = resistance breakpoints for azithromycin removed in 2019. Resistance was previously defined as >0.5 mg/L 3 = high-level azithromycin resistance is not defined by the European Committee on Antimicrobial Susceptibility Testing, but the definition in this figure is recognised internationally

Source  Source: Sources: Whittles LK, White PJ, Paul J & Didelot X[30], Public Health England[34]