Dyslipidaemia management
Lifestyle changes, such as smoking cessation, losing weight and increasing physical activity, can reduce cardiovascular risk for patients with dyslipidaema. Statins are used first line for most patients. Beyond statins, the National Institute for Health and Care Excellence suggests that ezetimibe in combination with statin therapy can be considered, but should be reserved until statin therapy has been fully optimised.
Summary
Lifestyle changes, such as smoking cessation, losing weight and increasing physical activity, can reduce cardiovascular risk for patients with dyslipidaema. Statins are used first line for most patients. Beyond statins, the National Institute for Health and Care Excellence suggests that ezetimibe in combination with statin therapy can be considered, but should be reserved until statin therapy has been fully optimised.
For patients unable to tolerate statins, fibrates, bile acid sequestrants, nicotinic acid derivatives and ezetimibe are all valid options. For patients with hypertriglyceridaemia, fibrates and omega-3 fatty acid compounds are useful, with or without statin therapy.
Helen Williams is consultant pharmacist for cardiovascular disease, medicines management team, Southwark Clinical Commissioning Group.
Citation: Clinical Pharmacist DOI: 10.1211/CP.2013.11125100
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