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Goserelin may be equivalent to chemotherapy for hormone-sensitive early breast cancer

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The Pharmaceutical Journal Vol 265 No 7118 p541
October 14, 2000 Clinical

Goserelin may be equivalent to chemotherapy for hormone-sensitive early breast cancer

Goserelin (Zoladex) is as effective as standard chemotherapy for hormone-sensitive early breast cancer, according to new research.
Results from the ZEBRA (Zoladex in early breast cancer research association trial) study were presented at a European breast cancer care conference in Brussels on September 28. The study involved 1,640 pre- and perimenopausal women with early breast cancer who received either goserelin 3.6mg every 28 days for two years or six 28-day cycles of standard chemotherapy (cyclophosphamide, methotrexate and 5-fluorouracil).
In patients who were hormone-sensitive (73 per cent of the study population), goserelin was shown to be equivalent to chemotherapy in terms of disease-free survival. In patients who were not hormone-sensitive, chemotherapy gave better results. Goserelin was associated with fewer adverse effects than chemotherapy.
Professor Mike Baum (emeritus professor of surgery, University College London, and chairman, Cancer Research Campaign breast cancer trials group) told The Journal on October 10 that the ZEBRA results were “impressive”. The study showed that in oestrogen receptor-positive patients, chemotherapy or goserelin gave equivalent outcomes. He said that women should be aware that there might be alternatives to chemotherapy if they were hormone-receptor positive. “The gold standard for treatment was chemotherapy and tamoxifen but we have now got sufficient evidence to suggest that ovarian suppression and tamoxifen is equivalent,” he concluded.

Citation: The Pharmaceutical Journal URI: 20003233

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