Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Uses for genetics in pharmacy

by Phillippa Brice and Simon Sanderson

Philippa Brice, PhD, is sciencepolicy and dissemination manager for the Public Health GeneticsUnit (part of the CambridgeGenetics Knowledge Park) where her work focuses on initiativesto stimulate the transfer of genetics research into clinical practice,and on the effective communication of genetics based knowledgeto health professionals. She previously worked in biomedical intelligencein the pharmaceutical industry.

Simon Sanderson, DPH, FFPHM, isclinical lecturer in primary care genetics in the Departmentof Public Health and Primary Care, University of Cambridge andpublichealth physician at the Public Health Genetics Unit

SUMMARY

Pharmacogenetics can be defined as the application of genetic analysisto predict drug response, efficacy and toxicity. More recently, sincecompletion of the Human Genome Project, the term “pharmacogenomics” hascome into common use (see Panel 1) but in this article, we will continueto use “pharmacogenetics”.

The discipline of pharmacogenetics dates back to the 1950s with the observationof variable inherited clinical responses to primaquine, isoniazid andthe anaesthetic succinylcholine. Primaquine can cause haemolytic anaemia in those withglucose 6-phosphate dehydrogenase (G6PD) deficiency, isoniazid is likely to causemore severe side effects in people who are “slow drug metabolisers”,and patients with a defective metabolising enzyme experience prolongedmuscle relaxation when succinylcholine is used. The DNA (deoxyribonucleicacid) sequences of the genes involved, however, have only recently been determined.

Full article PDF 80K

Citation: The Pharmaceutical Journal URI: 10002212

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary information

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.