Antibiotics can improve symptom resolution in otitis media
Treatment of children suffering from otitis media with amoxicillin plus clavulanic acid can reduce the time to resolution of symptoms, conclude the authors of a study published in the New England Journal of Medicine (2011;364:105).
Researchers randomised 291 children (aged six to 23 months) with otitis media to receive either amoxicillin plus clavulanic acid or placebo for 10 days.
The resolution of symptoms occurred by day 2 in 20% of the children given the antibiotic, by day 4 in 41%, and by day 7 in 67%; the corresponding values for children given placebo were 14%, 36%, and 53% (P=0.04 for the overall comparison).
Citation: Clinical Pharmacist URI: 11067334