Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.


Subscribe or Register

Existing user? Login

Antirheumatic drug with novel mechanism of action

Abatacept, the first in a new class of antirheumatic drugs called selective co-stimulation modulators, appears to offer pain relief and increased mobility in rheumatoid arthritis patients, US researchers say.

Abatacept has a novel mechanism of action. It works by selectively modulating the CD80- or CD86-CD28 co-stimulatory signal required for full T-cell activation. The researchers say that by modulating events “upstream” of T-cell activation, abatacept has the potential to affect multiple pathways further down. “Our data suggest that, in addition to playing a key role in the activation of naive T-cells that orchestrate early disease, co-stimulation continues to play a role in the pathogenesis of established, long-standing disease,” they add.

The researchers believe that, given the novel mechanism of action of abatacept and the recognised role of T-cells in rheumatoid arthritis, selective modulation of co-stimulation represents a rational therapeutic approach in patients with an inadequate response to anti-TNF-a therapy.

The phase III randomised controlled trial involved 391 patients with active RA and an inadequate response to anti-TNF-a therapy. Patients received either abatacept (n=258) or placebo (n=133) on days 1, 15 and 29, and every 28 days after that for six months, plus at least one other disease-modifying antirheumatic drug.

Results showed that the number of patients reaching a clinical improvement of at least 20 per cent (ACR20) at six months was higher in the abatacept than in the placebo group (50.4 per cent versus 19.5 per cent; P<0.001). Improvement was evident at day 15 and increased over the study period with ACR50 and ACR70 being higher in the abatacept group at six months (P<0.001 and P=0.003, respectively).

In addition, more patients in the abatacept group had clinically meaningful improvements in physical function (47.3 per cent versus 23.3 per cent; P<0.001) and in health-related quality of life (New England Journal of Medicine 2005;353:11).

Citation: The Pharmaceutical Journal URI: 10019039

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Drugs of Abuse

    Drugs of Abuse

    A concise, easy-to-read guide for healthcare professionals who encounter drug abuse.

    £38.00Buy now
  • Adverse Drug Reactions

    Adverse Drug Reactions

    A practical guide to the drug reactions that affect particular organ systems, and the management of these reactions.

    £38.00Buy now
  • English Delftware Drug Jars

    English Delftware Drug Jars

    This beautiful book illustrates the art and history of the collection of English delftware drug jars in the Museum of the Royal Pharmaceutical Society of Great Britain.

    £54.00Buy now
  • Paediatric Drug Handling

    Paediatric Drug Handling

    Written for new pharmaceutical scientists, this book provides a background in paediatric pharmacy and a comprehensive introduction to children's medication.

    £33.00Buy now
  • Introduction to Renal Therapeutics

    Introduction to Renal Therapeutics

    Introduction to Renal Therapeutics covers all aspects of drug use in renal failure. Shows the role of the pharmacist in patient care for chronic kidney disease.

    £38.00Buy now

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.