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Benefit from antidepressants linked to severity of depression

The benefit derived from antidepressant medicines increases as the severity of depression worsens, a meta-analysis suggests (JAMA 2010;303:47).

Data from six studies (718 patients in total) were included in the analysis. The authors conclude that antidepressants generate little or no benefit, compared with placebo, for patients with mild or moderate depression.

For severe cases they claim the benefit of treatment over placebo is substantial.

Citation: Clinical Pharmacist URI: 10994524

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