Combination of co-trimoxazole and renin/angiotensin drugs linked with hyperkalaemia
Combining co-trimoxazole with ACE inhibitors or angiotensin-II receptor blockers (ARBs) is associated with an increased risk of hyperkalaemia-related hospital admission among older patients (Archives of Internal Medicine 2010;170:1045).
In the analysis of 439,677 patients, concomitant co-trimoxazole use was associated with a sevenfold increased risk of admissions for hyperkalaemia compared with concomitant use of amoxicillin.
Trimethoprim (a component of co-trimoxazole) is structurally related to the potassium-sparing diuretic amiloride.
Citation: Clinical Pharmacist URI: 11016977
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