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Combination of co-trimoxazole and renin/angiotensin drugs linked with hyperkalaemia

By News team

Combining co-trimoxazole with ACE inhibitors or angiotensin-II receptor blockers (ARBs) is associated with an increased risk of hyperkalaemia-related hospital admission among older patients (Archives of Internal Medicine 2010;170:1045).

In the analysis of 439,677 patients, concomitant co-trimoxazole use was associated with a sevenfold increased risk of admissions for hyperkalaemia compared with concomitant use of amoxicillin.

Trimethoprim (a component of co-trimoxazole) is structurally related to the potassium-sparing diuretic amiloride.

Citation: Clinical Pharmacist URI: 11016977

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