Fluoroquinolones and acute kidney injury
Oral fluoroquinolones are associated with a small, but significant, increased risk of acute kidney injury, US researchers report (Canadian Medical Association Journal, online 3 June 2013).
A case-control study involving men aged 40 to 85 years found current quinolone use to be associated with a two-fold increased risk of acute kidney injury requiring hospital admission. The absolute increase was 6.5 events per 10,000 person years. There was a 4.5-fold increase in risk of acute kidney injury with combined use of quinolone and renin angiotensin system blockers, and the researchers caution against concomitant use.
Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2013.11122080