Cookie policy: This site uses cookies (small files stored on your computer) to simplify and improve your experience of this website. Cookies are small text files stored on the device you are using to access this website. For more information please take a look at our terms and conditions. Some parts of the site may not work properly if you choose not to accept cookies.

Join

Subscribe or Register

Existing user? Login

Clinical research

Interim results of stem cell treatment for multiple sclerosis show promise

Interim study data suggest haematopoietic cell transplant may induce sustained remissions in early MS.

MRI of multiple sclerosis in a 42 year old woman

Source: Cultura RM / Alamy

MRI scan of a patient’s brain reveals the neurological damage wrought by multiple sclerosis; most of the patients in the HALT-MS trial remained in remission and had improved neurological function at three years

Stem cell treatment after high-dose immunosuppressive therapy could be an effective way to manage relapsing-remitting multiple sclerosis, according to interim results from a five-year study[1] published in JAMA Neurology on 29 December 2014.

Researchers are following the progress of 24 patients with relapsing-remitting multiple sclerosis (RRMS) who received transplants of their own haematopoietic stem cells after receiving high-dose immunosuppressive therapy (HDIT). The phase II study, known as the HALT-MS trial, is testing whether control of inflammation earlier in RRMS may lead to prolonged remission and potentially reverse neurologic dysfunction. After three years without maintenance therapy, most of the patients remained in remission of active disease and had improvements in neurological function.

“Most patients with RRMS who receive approved disease-modifying therapies experience breakthrough disease and accumulate neurologic disability,” say the researchers, led by Richard Nash, of the Colorado Blood Cancer Institute, Denver. “High-dose immunosuppressive therapy with autologous haematopoietic cell transplant may, in contrast, induce sustained remissions in early MS.”

For the 24 patients who received HDIT with autologous haematopoietic cell transplant, the overall rate of event-free survival was 78.4% at three years (90% confidence interval 60.1%-89.0%) — this was defined as survival without loss of neurologic function, clinical relapse or new lesions observed on imaging. Progression-free survival and clinical relapse-free survival were 90.9% (90% CI 73.7%-97.1%) and 86.3% (90% CI 68.1%-94.5%), respectively. Improvements in neurologic disability, quality-of-life and functional scores were also noted.

The researchers report no unexpected side effects. “Most early toxic effects were hematologic and gastrointestinal and were expected and reversible,” they say, but warn that longer follow-up is needed to determine whether the response endures.

The findings are described as promising by the Multiple Sclerosis Trust, a UK charity. “Stem cell therapy for MS holds significant potential but remains at the frontier of clinical research,” says Amy Bowen, the charity’s director of service development.

However, the authors of an editorial[2] accompanying the JAMA Neurology study say “the jury is still out” on the appropriateness of haematopoietic cell transplant for MS.

“Nash et al show evidence of prolonged depletion of memory CD4+ cells, depletion of CD4+-dominant T-cell receptor clones and evidence of ‘immune reset’; however, clinical or radiologic evidence of relapse trumps immunologic evidence of immune reset, and this study raises concern that those end points have not been adequately achieved.”

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2014.20067495

Readers' comments (1)

  • A cure is needed, this disease was discovered over 150 years ago and affect 2.5 million people worldwide. This number is growing, and so many questions remain unanswered. We are all begging for this cure, the world needs to start healing again

    Unsuitable or offensive? Report this comment

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save
  • Print Friendly Version of this pagePrint Get a PDF version of this webpagePDF

Supplementary images

  • MRI of multiple sclerosis in a 42 year old woman

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.