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What is the situation with “smart drugs” use among UK university students?

We know that the use of cognitive enhancers among university students in the US has soared over the past few years, but what about in the UK? Adam Rathbone investigates

By Adam Rathbone

We know that the use of cognitive enhancers among university students inthe US has soared over the past few years, but what about in the UK? Adam Rathbone investigates

Many students go through huge amounts of stress at university trying to pull together essays in time for deadlines or cramming in some last-minute study before their examinations. Some students seem to thrive under this pressure but, for others, the stress can get too much. Yet there may be a solution.

Cognitive enhancers, or “smart drugs”, are products available that claim to enhance the taker’s motivation and ability to learn.

One recent graduate described taking a 10mg dose of methylphenidate as “amazing”. He took the drug approaching his final exams at university and felt that it “enhanced concentration”. But he believed that “long-term [it] will destroy your brain”. When asked why he used methylphenidate, he said “[I was] going through the motions back then and just needed focus.”

He obtained a supply of methylphenidate through a private prescription. He explained that “[this] won’t happen on the NHS. [It is] expensive but worth it.” A preregistration trainee, who wished to remain anonymous, said “people take them if they need them, fair enough” and, while she was at university, a student offered smart drugs to a friend to complete some of her work, referring to the drug as “paracetamol”. She had refused similar offers herself on numerous occasions, stating: “I don’t like taking [medicines] when I’m sick, never mind to study.”

One preregistration trainee thought “a smart drug was a drug to help make you concentrateand stay alert. If you count ProPlus then I guess I used one too, but it didn’t really work out for me so I changed my revision technique.” She went on to say: “It would be unfair to use restricted medicines, like modafinil and Ritalin, to improve your cognitive function, unless you had a diagnosed problem.” For the students whom she knew had used prescription-only medicines, cost had not been an issue. “It was easy to see which students were studying hard naturally and which students were using an [enhancer],” she said. “I think it’s really damaging. The majority of students who take smart drugs look as if they put a lot of pressure on themselves towards the end of the year.” She thinks that taking something to help pass an exam is not justified because it does not reflect that person’s true ability.

Use in the UK

In total 108 year 4 pharmacy students from one university were asked eight questions relating to smart drugs in a survey. Of those students who completed the survey, 92 per cent did not know what a smart drug was. One pharmacy student, who had not previously heard of smart drugs, commented: “I saw it in a movie but not in real life.”

Before answering further questions, the students were given a brief definition of smart drugs and their cognitive-enhancing properties. After that, 24 per cent of students answered “yes” when asked if they knew if smart drugs or similar products were available, suggesting that students do know smart drugs are available but perhaps call them something different.

Six per cent of students admitted to using a smart drug to help them study in the past and 46 per cent said they would consider using a smart drug. Over half of the students (62 per cent) answered “yes” when asked if they had ever used caffeine or caffeinated products to help them study and 53 per cent said cost would not impact heavily on their decision to use a smart drug.

When asked if they considered using a smart drug as cheating, 78 per cent answered “no”. One student added: “It depends. Some people are not naturally fast thinkers.” The final question on the survey asked: “Do you think it is OK to use a medication to help you pass an exam if this does not reflect your usual day-to-day cognitive ability?” The results showed that 58 per cent answered “yes” and 42 per cent answered “no”. One pharmacy student answered: “No, it’s not okay — not if only certain individuals are using it.” Another answered: “No, it’s definitely not okay. If you sit an exam with this thing, it means you might as well take it for the rest of your life while you work, just to make sure you don’t wind up [making a lethal dispensing error] and killing somebody.”

In an online version of the same survey (n=72), 10 per cent of respondents reported using a smart drug and 32.9 per cent of online respondents had heard of smart drugs. Of the online respondents (28 per cent male, 72 per cent female) 84 per cent were aged 16–25 years and 78.7 per cent identified themselves as a healthcare sciences student. Results showed 58.6 per cent would not consider using a smart drug as cheating.

Varsity, Cambridge University’s student paper, reported in March 2009 that 10 per cent of students at Cambridge had admitted to taking medicines without a prescription to help them work.1 Compare this with the US, where 6 per cent of students who answered a web-based survey had used a prescription stimulant in the past year. Of this group, 75.8 per cent used the combination product Adderall (amphetamine-dexamphetamine combination) and 24.5 per cent used methylphenidate.2 The study also assessed motives for use, reporting concentration (65.2 per cent), to help study (59.8 per cent) and to increase alertness (47.5 per cent) as the most common.2

A 2008 poll of Nature readers reported “one in five used drugs for non-medical reasons to stimulate their focus, concentration or memory.3 Of those who had used a smart drug, 62 per cent of respondents had used methylphenidate, 44 per cent used modafinil and 15 per cent used beta-blockers.3

On discussing the use of smart drugs with some graduate medical students, one said: “I wouldn’t think twice about using a drug like that if I could afford it. It’s no worse than coffee or Red Bull.” Another medical student said he considered using a smart drug as cheating and did not think it was OK to use drugs to help you pass an exam. The Journal previously published an article on the ethics of using cognitive enhancers (PJ 2008;280:684).

In 2009, Nouse, the University of York’s student newspaper, published the experiences of three young men who would take modafinil for just under a week and note the side effects. One of the students, describing a typical evening, said: “I take the drug with dinner, go to the pub with my friends and maybe watch a film, before getting in at around 1am and working for another eight hours.”4

Students who have taken modafinil report feeling “more motivated”, improving their ability to concentrate and work.1 Although some claim modafinil allows them to be more sociable by completing their assignments more efficiently and so freeing time to go to the pub, others report feelings of despondency and antisocial behaviour.1

Stance of universities

Although athletes are advised to check with the appropriate authority before they take any medicine that may improve their athletic ability, students are in a different position. Of the UK universities asked (n=9), none had guidance in place relating to the use of smart drugs or cognitive enhancers. One of the top-ranking universities in the UK said that “the university does not have a specific rule prohibiting the use of legal prescription drugs. However, it would strongly advise students against taking drugs that have not been specifically prescribed to them, as this is dangerous and can be illegal.” Another university legal department said it “would only take action where illegal substances are being used in the same way as the police would prosecute”.

The assistant registrar of one university replied: “No, we don’t have any specific reference to smart drugs in our policies and this issue is not currently under consideration for specific inclusion. I don’t know of any reported incidences or suspicions raised around students abusing or using smart drugs.”

Availability

These drugs are available to just about anyone with access to the internet. Although modafinil and methylphenidate are prescription-only medicines (the latter being a Controlled Drug as well), the internet proffers them without any form of consultation or healthcare professional input. Free next-day delivery is usually available at no extra cost. Prices vary depending on the supplier. One online retailer offers 50 blister-packed modafinil 200mg tablets for £124.99, including free special delivery. The same retailer also gives the address of a Yorkshire-based pharmacy. However, a quick check on the General Pharmaceutical Council’s website disproves that the address is home to a registered pharmacy premises .

The Medicines and Healthcare products Regulatory Agency said: “We urge patients to obtain their prescription medicine through a registered pharmacy or a GPhC-approved website. Purchasing medicines from any other source, particularly from a website based overseas, is potentially a risk to health. There is no guarantee that medicines purchased online meet the set standards of quality and safety that are mandatory in the UK.”  Members of the public are encouraged to report any concerns over the legitimacy of an online pharmacy to the MHRA.

Conclusion

Smart drugs are only going to become more popular and, with time, popping a pill on your way to work or university may become the norm.

Modafinil and methylphenidate

The two most common drugs used as smart drugs are modafinil and methylphenidate.

Modafinil

Modafinil is a prescription-only medicine with a licensed dose range from 200–400mg daily. Historically used to treat daytime sleepiness the drug has also been used to improve cognition in other conditions, including multiple sclerosis and hyperactivity disorders. However, in July 2010, the European Medicines Agency’s Committee for Medicinal Products for Human Use reported that the risks associated with modafinil were only outweighed by the benefits in patients with narcolepsy, resulting in all other indications being withdrawn from the drugs marketing authorisation.1 Modafinil has also been prescribed for shift-workers, members of the armed forces, pilots and nurses suffering with shift-worker sleep disorder.

The precise mode of action of modafinil is unknown.  An evidence-based review concluded “a single dose of modafinil improved the ability of emergency room physicians to attend didactic lectures after a night shift, but did not improve their ability to drive home. It did not provide any benefit greater than placebo.2 Research conducted by the University of Cambridge in 2003 showed that a single oral dose of modafinil enhanced performance on tests of cognition in healthy young men.5 Participants in the randomised double-blind study reported feeling “more alert, attentive and energetic”.5

Methylphenidate

Methylphenidate is a schedule 2 Controlled Drug indicated as part of a comprehensive treatment programme for attention deficit-hyperactivity disorder (ADHD)6 but has also been used as a smart drug.

Commonly known as kiddie cocaine, ritie or vitamin R, methylphenidate is an amphetamine-like compound. The drug’s mode of action is not completely understood.6

Research from nearly 15 years ago shows that a single dose of methylphenidate can improve spatial working memory and planning performance in healthy young men.7 Intranasal use of methylphenidate, that is, crushing the tablet and inhaling the powder, is less popular than taking the drug orally. However, this method of administration can produce a high equal to that of cocaine.8–10

 

Related articles

Cognitive enhancers: what they are, how they work and what is in the pipeline

What are university students’ views on the self-prescribing of “smart drugs”? 

 

 

 

References

1 Lennard N. One in ten takes drugs to study. Available at: www.varsity.co.uk (accessed 31 December 2012).

2 Wesensten NJ, Reichardt RM, Balkin TJ. Ampakine (Cx717) effects on performance and alertness during simulated night shift work. Aviation, Space and Enviromental Medicine 2007;78:937–43.

3 Maher B. Poll results: Look who’s doping. Nature 2008;452:674–5.

4 Modafinil: the new wonder drug? Available at: www.nouse.co.uk (accessed 31 December 2012).

5 Turner DC, Robbins TW, Clark L et al. Cognitive enhancing effects of modafinil in healthy volunteers. Psychopharmacology 2003;165:260–9.

6 Coull JT, Middleton HC, Robbine TW et al. Contrasting effects of clonidine and diazepam on tests of working memory and planning. Psychopharmacology 1995;120:311–21.

7 Elliot R, Sahakian BK, Matthews K et al. Effects of methylphenidate on spatial working memory and planning in healthy young adults. Psychopharmacology 1997:131:196–206.

8 Volkow ND, Ding YS, Fowler JS et al. Is methylphenidate like cocaine? Studies on their pharmacokinetics and distribution in the human brain. Archives of General Psychiatry 1995;52:456–63.

9 Volkow ND, Wang GJ, Fowler JS et al. Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers: implications in addiction. American Journal of Psychiatry 1999;156:19–26.

10 Morton WA, Stockton GG. Methylphenidate abuse and psychiatric side effects. Primary Care Companion to the Journal of Clinical Psychiatry 2000;2:159–64.

Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2013.11117393

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