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NICE endorses golimumab second line for rheumatoid arthritis

By News team

The National Institute for Health and Clinical Excellence has endorsed golimumab as a second-line option for treating rheumatoid arthritis.

New guidance published today (22 June 2011) recommends golimumab (Simponi: Schering-Plough) in combination with methotrexate in adults whose rheumatoid arthritis has responded inadequately to conventional disease-modifying antirheumatic drugs (DMARDs), including methotrexate.

NICE advises that use of golimumab should follow guidance for other tumour necrosis factor (TNF) inhibitor treatments — adalimumab, etanercept and infliximab — covered by NICE technology appraisal 130.

Another condition set by NICE is that the manufacturer provides the 100mg dose of golimumab at the same cost as the 50mg dose.

For adults whose rheumatoid arthritis has responded inadequately to other DMARDs, including a TNF inhibitor, and who cannot take rituximab, golimumab in combination with methotrexate is also recommended as a treatment option, subject to certain provisos.  

NICE, however, is not recommending golimumab for methotrexate-naive rheumatoid arthritis, due to a lack of evidence.

Citation: The Pharmaceutical Journal URI: 11079292

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