Natecal D3 interactions update
The summary of product characteristics of Natecal D3 (calcium carbonate and cholecalciferol; Chiesi) 600mg + 400 I.U. chewable tablets now warns that the calcium and alkali intake from other sources (food, dietary supplements and other drugs) should be taken into consideration when prescribing calcium supplements. If very high doses of calcium are taken concomitantly with absorbable alkali agents (like carbonate), this could lead to milk-alkali syndrome. In addition, it states that rifampicin may reduce the activity of vitamin D3, since it increases the rate of its metabolism.
Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2015.20068955
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