Reduced efficacy of benzodiazepines with Xenical
The summary of product characteristics for Xenical (orlistat; Roche) now states that there are some case reports of reduced efficacy of benzodiazepines coincidental to the initiation of orlistat treatment in previously well controlled patients. Therefore, orlistat treatment should only be initiated after careful consideration of the possible impact in these patients.
Citation: The Pharmaceutical Journal DOI: 10.1211/PJ.2015.20200075
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