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NSAIDS may increase risk of miscarriage

By Clinical Pharmacist

Use of non-steroidal anti-inflammatory drugs during pregnancy may increase the risk of miscarriage, suggests research published online in CMAJ (6 September 2011).

Using the Quebec Pregnancy Registry, non-aspirin NSAID?use was gleaned from prescription data for 4,705 women who had miscarried within 20 weeks of gestation and for 47,050 matched case controls.

The use of NSAIDs other than aspirin was associated with an increased risk of spontaneous abortion (odds ratio 2.43, 95% confidence interval 2.12–2.79). No dose-response effect was observed. 

Citation: Clinical Pharmacist URI: 11085479

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