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The Pharmaceutical Journal
From Mr T. Harris, FRPharmS
In my opinion I. ab I. Davies (PJ, 3/10 January, p15) has succeeded only in creating problems which do not exist. He has not mentioned the cardinal fact that alcohol is completely miscible with water and negligibly so in fat. Thus when alcohol is consumed, after absorption from the gut it is distributed exclusively throughout the body water (extracellular and intracellular) including, of course, the blood.
Maximum BAC =
Weight of alcohol consumed
and Vd = (0.72 / 0.85) (1 - F/100) W
where F = percentage fat content of body weight (W) and blood contains 85 per cent water
An algorithm established by experiment gives a reasonable estimate of F:
For males F = (BMI x 1.34) – 12.47
where BMI = body mass index
In practice the maximum BAC is never achieved because of metabolic loss of alcohol during and following absorption. I cannot agree with Dr Davies’s theory that a difference in liver size between the sexes is the reason for women having a higher BAC than men after taking the same oral dose of alcohol.
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Citation: The Pharmaceutical Journal URI: 20011095
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